scaffolds – TechConnect Briefs

Three-Dimensional Macroporous Carbon Nanotube Scaffolds for Stem Cell Expansion and Maintenance

Lalwani G., Gopalan A., D’Agati M., Patel S., Talukdar Y., Sitharaman B., Stony Brook University, US

Expansion of stem cells and maintenance of their self-renewal capacity in vitro requires specialized robust cell culture systems. Conventional approaches consisting of animal derived matrices and cocktail of growth factors have limitations such as consistency, [...]

Three-dimensional cell instructive scaffolds to direct stem cell fate

Viswanathan P., Chirasatitsin S., Reilly G., Engler A., Battaglia G., University of Sheffield, UK

Novel biomaterials design rarely incorporates the range of topographical (10nm – 100um) and chemical cues required to influence cell behaviour. Of particular interest is controlling human mesenchymal and embryonic stem cell fate. Recently it has [...]

Titanium Tungsten Coatings for Bioelectrochemical Applications

Wierzbicki R., Amato L., Lopacinska J., Heiskanen A., Emneus J., Boggild P., Molhave K., DTU Nanotech, DK

Our research interest is the combination of carbon nanotube electrochemistry with nanostructured substrates capable of cell scaffolding. Therefore, an adhesion / electric connection coating with good biocompatibility, PECVD compatibility and electrochemical stability needs to be [...]

Novel Resorbable Drug-Carrying Nano-Scaffolds for Treating Bone Diseases at Targeted Sites

Liu H., Webster T.J., Brown University, US

Pharmaceutical agents are often required to stimulate new bone formation for the treatment of bone injuries or diseases (such as osteoporosis and osteosarcoma). However, there are several problems associated with current drug delivery methods. First, [...]

Sprayed Nanogels onto 2D and 3D Scaffolds as Novel Drug Eluting Coatings

Juan MJ., Olalde B., Jurado MJ., Saez-Martinez V., INASMET-Tecnalia, ES

Big advances are being achieved in the design of new implantable devices. The implant-induced inflammatory reaction remains a significant challenge in this field. Coated scaffolds capable of releasing bioactive agents for inhibiting totally or partially [...]

Structure Based Design of Protein Ligands: A Study of Antibody-like Scaffolds Targeted Against the Anthrax Toxin

Shiflett P., Hong-Geller E., Allen D., Lauer S., Lehnert B., Lehnert N., Nolan J., Lehnert B., Lehnert N., Gupta G., Los Alamos National Laboratories, US

We have adopted structure-based approaches to enhance the affinities of two single chain antibodies, scFv1 and scFv4, that bind to two different epitopes on the Protective Antigen (PA), a toxin from Bacillus anthracis. In one [...]