scaffold – TechConnect Briefs

Exploring Bacterial Interactions of Expanded-PTFE in the Presence of PVP-coated Silver Nanoparticles, Peptides p753 and p359 in 2D and 3D models

Finkle M., Meléndez Navarro P., Vig K., University of Nevada-Las Vegas, US

Tissue engineering is recognized as an avenue to improve treatment for various diseases. Expanded-PTFE (ePTFE) has gained popularity as a tissue scaffold to develop a vascular graft for generating blood vessels in cardiac surgeries. However, [...]

Bacteria Inhibitory Action of Peptides P753 and P359 in 2D and 3D Cell Cultures

Masuda J., Vig K., University of Hawaii at Manoa, US

The current study investigated two proprietary peptides, p359 and p753, for their antibacterial activity against Escherichia coli (E.Coli) and Staphylococcus aureus (S. aureus). Minimum Inhibitory Concentration (MIC) of bacteria for p359 and p753 was 50μg/mL [...]

Hydrogel-based scaffolds for tissue engineering

Joshi S., Singh S.R., Alabama State University, US

Gels or hydrogels are described as the matrix of cross-linked polymers. Hydrogels are naturally a part of the body in the form of collagen, gelatin, mucous, tear films, cartilage, vitreous humor, cornea, and tendon. The [...]

Enhanced Mechanical and Cytocompatibility Properties of Novel 3D Printed Osteochondral Scaffolds

Holmes B., Zhang LG., The George Washington University, US

A series of novel 3D osteochondral computer aided models were designed including a homogenous cross-hatched structure, a bi-phasic structure consisting of a cross hatched pattern and an intersecting rings structure, and a biphasic “key” model [...]

Biomimetic Biphasic Nanocomposite Scaffold for Osteochondral Regeneration

Castro N.J., O’Brien C., Zhang L.G., The George Washington University, US

The current work focused on the development and evaluation of a novel biomimetic biphasic nanocomposite scaffold for osteochondral interfacial tissue engineering. Tissue-specific growth factor-encapsulated nanospheres were manufactured via a wet electrospray technique and incorporated within [...]

Tuning Wettability of Electrospun Three-dimensional Scaffolds through Morphology Control

Ahmed F., Choudhury N.R., Dutta N.K., University of South Australia, AU

Surface wettability plays an important role in determining implant’s fate due to direct influence of protein/biomolecule adsorption that governs cell adhesion. The importance of the physical parameters, such as, overall porosity, pore directionality, difference between [...]

Osteogenic induction on single-walled carbon nanotube scaffolds

Zanello L.P., Sharma P., Corzano R., Hauschka P., University of California Riverside, US

Production of bone materials is the result of secretory activities by osteoblasts, the bone-forming cells. In the fractured and wounded bone, successful repair and/or regeneration depends on the capacity of osteoblast precursors to proliferate and [...]

A Novel Biodegradable System Based on BSA/PCL Core-shell Structured Nanofibers for Controlled Drug Delivery

Feng Y., Zhang Y.Z., Yong T., Ramakrishna S., National University of Singapore, SG

Electrospun core-shell structured nanofibers encapsulating BSA were explored as a potential drug delivery model in a biological system in present study. These nanofibers were prepared by coaxial electrospinning method with poly (caprolactone) (PCL) as the [...]

Guided Neurite Growth on Patterned Carbon Nanotubes

Zhang X., Prasad S., Niyogi S., Ozkan C.S., Ozkan M., Ozkan C.S., Ozkan M., University of California Riverside, US

Nanomaterials substrates are suitable for functioning as cell scaffolds. Promotion of axonal growth and support for long distance regeneration are the two requirements in the various experimental strategies for spinal cord repair. Organic systems’ performance [...]