Biomimetic Biphasic Nanocomposite Scaffold for Osteochondral Regeneration

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The current work focused on the development and evaluation of a novel biomimetic biphasic nanocomposite scaffold for osteochondral interfacial tissue engineering. Tissue-specific growth factor-encapsulated nanospheres were manufactured via a wet electrospray technique and incorporated within the respective layer of our biphasic model. Human bone marrow derived mesenchymal stem cells were seeded, cultured, and evaluated. Two-week differentiation results illustrated increased collagen and calcium deposition on nanosphere containing scaffolds when compared to other test samples.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: May 12, 2013
Pages: 183 - 186
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topic: Biomaterials
ISBN: 978-1-4822-0586-2