proteins – TechConnect Briefs

Carbon nanotubes functionalized neural probe platform for characterization of cell attachment and motility

Tyson J., Tran M., Patrick T., Slaughter G., University of Maryland Baltimore County, US

The application of micro- or nano-electromechanical systems (MEMs) or (NEMs) to the fabrication of neural probes, have led to the development of minimally-invasive high density probes. Although the majority of neuroMEMs probes have been used [...]

Effects of CdTe QDs on protein structural changes

Ma X., Liang X., Liu L., Hu X., Fan J., Northwest University, CN

The nano-scale material, quantum dots (QDs), has been widely used in biological labels, imaging of fixed cells and tissues due to their excellent properties, such as small size, large surface area, good photostability, and negligible [...]

Surfactant Effect on Intercellular Transport of DNA, Proteins, and Electrolytes

Assan D., Gao X., Lai J.C.K., Leung S.W., Idaho State U, US

Surfactants play a key role on bodily functions at molecular level, such as cell signaling and signal transmission. Their importance in cell survival is well recognized, but the surfactant effect on intermolecular/interfacial mass transport is [...]

Bimolecules in multimodal and multifunctional bioimaging database: potentials and applications

Sharma A., Sharma R., Sharma A., Sharma R., Innovations and Solutions Inc., US

Oligonucleotides are biomarkers in gene expression imaging and proteins for imaging proteomics based on these end product molecules as visible by MRI and PET to give structural and metabolic information in diseased tissue. We compiled [...]

Creation of Protein Nanoarrays using Dip-Pen Nanolithography

Thompson D.G., McKenna E., Pitt A., Graham D., University of Strathclyde, UK

This presentation describes the creation of protein nanoarrays on a nitrocellulose surface using Dip-Pen Nanolithography and their use in studying protein:protein interactions in an assay format.

Nanomonitors: Electrical Immunoassays for Protein Biomarker Profiling

Bothara M.G., Reddy R.K., Barrett T., Carruthers J., Prasad S., Portland State University, US

Robust diagnosis of a disease can be accomplished by reliable detection of multiple protein biomarkers. Traditional assay methods for protein detection such as enzyme-linked immunosorbent assay (ELISA) have several limitations – need for use of [...]

Iridium Oxide Nanowire Monitors for Protein Detection

Venkatraman V.L., Reddy R.K., Zhang F., Hsu V., Ulrich B., Prasad S., Portland State University, US

The overarching research objective is the development of a “point-of-care” immunoassay device based on iridium oxide nanowires for disease state identification to predict human health outcomes. This device is based on electrical detection of proteins [...]

Nanoporous Alumina Membranes Based Microdevices for Ultrasensitive Protein Detection

Bothara M.G., Reddy R.K., Barrett T., Carruthers J., Prasad S., Portland State University, US

This research focuses on using the electrical and chemical properties of nanoporous alumina membranes to improve the sensitivity and performance of Si-based microdevices for protein sensing. The integration of nanoporous membranes with the microdevice results [...]

Advanced CryoTEM and Tomography for Two- and Three-Dimensional Nano-Characterisation of Soft Matter

Sourty E., de Haas F., Frederik P.M., Frederik P.M., Loos J., Stokes D.J., Hubert D.H.W., FEI Company, NL

Recent advances in transmission electron microscopy (TEM) mean that we are able to achieve unprecedented resolution at the atomic level. Furthermore, improved methods for obtaining and reconstructing tilt series projections allow us to create high [...]

Development of a specific micro/nanodevice validating the concept of molecular biopsy

Berger F., Bouamrani A., Cosnier M., Martin F., Caillat P., Benabid A.L., Inserm, FR

The nanomedicine concept implies early detection at the molecular level and molecular characterisation to implement a specific therapy. In this context, the development of micro/nanotool devoted for intra-tissular characterisation is indispensable. We first demonstrated that [...]