nanowired delivery – TechConnect Briefs

Nanodelivery of Chinese traditional medicine extract of Gingko Biloba (EGb-761) induces superior neuroprotection following traumatic brain injury in heat stroke

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Zhang Z-q, Li C., Patnaik R., Tian Z.R., Ozikzilcik A., Sharma A., Sharma H.S., Uppsala University, Uppsala, SE

Military personnel are often exposed to high summer heat resulting in heat stroke (HS) and related illnesses. HS often results in serious mental and physical consequences due to breakdown of the blood-brain barrier (BBB) to [...]

Intraspinal administration of TiO2 nanowired cerebrolysin with mesenchymal stem cells has superior neuroprotective effects on cord pathology and functional outcome following a focal spinal cord trauma

Feng L., Sharma A., Sharma H.S., Niu F., Huang H., Lafuenta J.V., Muresanu D.F., Ozkizilcik A., Tian Z.R., Sharma A., Sharma H.S., Bethune International Peace Hospital, CN

Military personnel are often victims of spinal cord injury (SCI) for which there is no suitable treatment available. Thus, exploring new therapeutic avenues using select combination of novel neuroprotective agents is the need of the [...]

Nanodelivery of Cerebrolysin Induces Profound Neuroprotection in Heat Stroke Following Chronic Hypertension in Combination with SiO2 and Carbon Nanoparticles Induced Exacerbation of Brain Damage

Muresanu D.F., Sharma A., Sharma H.S., Patnaik R., Nozari A., Mössler H., Tian Z.R., Ozkizilcik A., Sharma A., Sharma H.S., Uppsala University, SE

Our military personals are often exposed to combat stress induced hypertension in an environment rich in various nanoparticles emanating from different sources e.g., gun powder explosion or blast injuries. Furthermore, combat or peacekeeping activity in [...]

Nanodelivery of Cerebrolysin as adjunct therapy with Functionalized magnetic iron oxide nanoparticles enhances neuroprotection

Sharma A., Sharma H.S., Muresanu D.F., Tian Z.R., Moessler H., Sharma A., Sharma H.S., Uppsala University, SE

1. Functionalized magnetic iron oxide nanoparticles (FMIONPs) are used as adjunct therapy in cancer to effectively enhance cellular damages of cancerous cells sparing normal cells using chemotherapy or heat treatment. The FMIONPs are considered safe. [...]

TiO2-Nanowired cerebrolysin attenuated hyperthermia induced ubiquitin overexpression and brain pathology

Sharma A., Sharma H.S., Muresanu D.F., Patnaik R., Moessler H., Sharma A., Sharma H.S., Uppsala University, SE

1. Hyperthermia and heat stress induces brain damage. This is specially applicable to Military personals during combat operations in the Middle East where heat is a big problem 2. Intoxication of nanoparticles exacerbates heat-induced brain [...]