microfluidic – Page 4 – TechConnect Briefs

High Sensitivity, Microfluidic Immunoassays utilizing DNA-conjugated Antibodies to Accelerate the Electrophoretic Separation of Antigen-Antibody Complexes

Wada H.G., Kawabata T., Kazakova I., Simeonov A., Park C., Kechagia P., Spaid M., Watanabe M., Satomura S., Wako Pure Chemical Industries Ltd., US

The promise of microfluidic immunoassays in microchips has been the miniaturization, integration and automation of rapid immunoassays. The typical microfluidic assays have used fluorescent dye labeled antibodies in direct binding assays or labeled antigens in [...]

Fast DNA Hybridization on a Multi-Sample Multi-probe Microfluidic Microarray Compact Disc

Peng X.Y., Li P.C.H., Yu H-Z, Parameswaran A.M., Beardmore S., Chou W.L., Simon Fraser University, CA

DNA microarrays are usually constructed using photolithographic synthesis of oligonucleotide probes or by spotting of pre-synthesized probes. These are expensive methods, and only one sample can be applied on a microarray chip at one time. [...]

An Injector Component Model for Complete Microfluidic Electrokinetic Separation Systems

Magargle R., Hoburg J.F., Mukherjee T., Carnegie Mellon University, US

This work presents a closed-form, numerically derived model of a key microfluidic electrokinetic separation system component, the cross injector. The model fits into a framework such that it can be combined with a network of [...]

Macromolecules in Microdevices: Multiscale simulation of DNA dynamics in model microfluidic geometries

Jendrejack R.M., de Pablo J.J., Graham M.D., University of Wisconsin-Madison, US

Simple arguments predict that the dynamics of a dissolved macromolecule confined to a channel comparable to its equilibrium coi size (~1 um for viral DNA) are quite different from those in free solution, because of [...]

Macromolecules in Microdevices: Multiscale simulation of DNA dynamics in model microfluidic geometries

Jendrejack R.M., de Pablo J.J., Graham M.D., University of Wisconsin-Madison, US

Simple arguments predict that the dynamics of a dissolved macromolecule confined to a channel comparable to its equilibrium coil size (~1 um for viral DNA) are quite different from those in free solution, because of [...]

Computational Modeling of Microfluid Devices with Free Surface Liquid Handling

Yang H.Q., Przekwas A.J., CFD Research Corporation, US

Integrated Microfluidic Systems are the subject of great scientific and commercial interest for a wide range of applications, including the biomedical, environmental, automotive, aerospace, and defense. This paper presents the computational methodology used in the [...]

Finite Element Approach for Reactive Microfluidic Devices

Hsing I-M, Srinivasan R., Jensen K.F., Schmidt M.A., Hong Kong University of Science and Technology, HK

We report a finite element method (FEM) based model for simulating microfluidic devices with chemical reactions. The simulation approach incorporates a general mesh generation procedure, which allows us to explore different application-oriented designs of microfluidic [...]