microchannel – Page 2 – TechConnect Briefs

Simulation of a Microfluidic Particle Concentrator and Separator

Chen C.C., Auner G.W., Industrial Technology Research Institute, TW & Wayne State University, US

A flow-through micro polymerase chain reaction (PCR) chip was optimized by using coupled multiphysics computational tools. Comprehensive simulations of temperature and flow profiles were presented for the denaturation, extension, and annealing zones on the flow-through [...]

Macromodeling for Microfluidic Channels

Kuo C-W, Chein C-M, Yang Y-J, National Taiwan University, TW

In this paper, we present a methodology of generating microfluidic macromodels (reduced-order models) for 3-D non-linear microchannels. Compared with the full-meshed simulations, the generated macromodels not only provide accuracy results, but also give three-orders-of-magnitude speed-ups. [...]

Microchannel Reactor Stacked by Brazing Method

Yu S.P., Lee S.J., Lee W.Y., Kim C.S., Lee S.J., Lee W.Y., Song K.S., Korea Institute of Energy Research, KR

Each stack of microstructured stainless steel and aluminum plates was coated and brazed in vacuum. As a supporter of catalyst, the coating layer was formed by sol-gel method and anodizing respectively. Though the number of [...]

Clogging Pressures of Bubbles in Microchannel Contractions: Theory and Experiments

Jensen M.J., Wang X., Attinger D., Bruus H., Mikroelektronik Centret, DTU, DK

We present a theoretical, numerical, and experimental study of bubbles passing through a microchannel contraction. A certain pressure, the so-called clogging pressure, is needed to push a bubble through a microchannel contraction. We present the [...]

Capillary Passive Valve in Microfluidic System

Cho H., Kim H-Y, Kim T.S., Kang J.Y., Kim H-Y, Kim T.S., Microsystem Research Center, Korea Institute of Science and Technology, KR

This work reports the theoretical and experimental investigations of capillary bust valves to regulate liquid flow in microchannels. The theoretical analysis uses the Young-Laplace equation and geometrical considerations to predict the pressure at the edge [...]

Highly Efficient Electro-permeabilization of Mammalian Cells Using Micro-electroporation Chip

Shin Y.S., Kim J.K., Lim S.H., Lee Y., Lee Y.K., Cho K., Lee Y., Lee Y.K., Chung C., Chung S., Chung C., Chung S., Han D-C, Chang J.K., Seoul National University, KR

Electroporation, is widely used method that can be directly applied to the field of gene therapy. However, very little is known about the basic mechanisms of DNA transfer and cell response to the electric pulse. [...]

A Study on the Novel Type of Ferrofluid Magnetic Pipette

Ahn J.J., Oh J., Choi B., Sogang University, KR

This study was performed to design the novel type of ferrofluid magnetic pipette on a micro scale for the purpose of applications to delivery systems, which is the core device of Lab on a chip [...]

Modeling of Surface Tension in Fluidic MEMS Using the Level-Set Method

Takahashi K., Kyushu University, JP

Mixed state of liquid and gas is frequently seen in fluidic MEMS, for example, ink jet printer, heat exchanger, thermo-capillary optical switch, and so on. The surface tension is the most dominant mechanical effect in [...]

Study of Sample Dispersion Mechanisms in an Electroosmotically Pumped Microchannel

Debusschere B., Najm H., Matta A., Knio O., Ghanem R., Le Maitre O., Sandia National Laboratories, US

In many microfluidic separation processes, dispersion of sample peaks is a significant problem limiting the detection resolution. In this work, we use simulations to study the dominant dispersion mechanisms during a protein labeling process in [...]

Highly Integrated Transparent Microchannel Chips for Continuous-flow PCR

Sun K., Matsuo S., Misawa H., Satellite Venture Business Laboratory, The University of Tokushima, JP

A microchannel chip for continuous-flow polymerase chain reaction (PCR) was developed using transparent materials. The microchannel was fabricated on a quartz glass substrate using standard photolithography and wet-etching techniques, and was sealed by another quartz [...]