microarray – Page 2 – TechConnect Briefs

A Droplet Microarray for Homogeneous Enzymatic Assay

Balakirev M., Mugherli L., Chatelain F., CEA-Grenoble, FR

This work describes a droplet microarray for monitoring of enzymatic activity on a glass slide. These array are composed of features defined and separated by differential surface tension (surface tension array). A photolithographic method was [...]

Flat Fluidics: Programmable On-Chip Networks for Biological and Chemical Applications

Wixforth A., University of Augsburg and Advalytix AG, DE

We present a novel approach towards the needs of a versatile microfluidic chip-based microfluidic system with unique properties and functionality. Like for microarrays and in contrast to many existing microfluidic technologies, the fluid handling is [...]

Design and Applications of a Novel Type of Hairpin Probes: Addressable Bipartite Molecular Hook (ABMH)

Landré J.B.P., Ruryk A., Schlicksbier T., Russwurm S., Deigner H.-P., University of East Anglia, UK

ABMHs but not TMBs display the characteristic melt curves obtained with MBs. Moreover, ABMHs specificity in solution (Figure 2) is similar to those of MBs (i.e. differentiation between a perfect match and a 1 mismatch [...]

Enhancement of DNA Microarray Hybridization using Shear-Driven Microfluidics

Vanderhoeven J., Pappaert K., Dutta B., Vanhummelen P., Baron G.V., Desmet G., Free University of Brussels, BE

On microarrays the transport of the target molecules towards the spots only occurs by molecular diffusion. As a result, microarray analyses require overnight incubation and are highly inefficient in terms of capture rate and detection [...]

Fast DNA Hybridization on a Multi-Sample Multi-probe Microfluidic Microarray Compact Disc

Peng X.Y., Li P.C.H., Yu H-Z, Parameswaran A.M., Beardmore S., Chou W.L., Simon Fraser University, CA

DNA microarrays are usually constructed using photolithographic synthesis of oligonucleotide probes or by spotting of pre-synthesized probes. These are expensive methods, and only one sample can be applied on a microarray chip at one time. [...]

High-Resolution Electrochemical In Situ Printing

Egeland R.D., Southern E.M., Oxamer & Oxford Gene Technology, UK

This work demonstrates a new method for making oligonucleotide microarrays by synthesis in situ. The method uses conventional DNA synthesis chemistry with an electrochemical deblocking step. Acid is delivered to specific regions on a glass [...]

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