micro fluidics – TechConnect Briefs

Recent advances in capillary microflows for point-of-care and home-care devices

Berthier J., Gosselin D., Huet M., Cubizolles M., Delapierre G., CEA/LETI/MINATEC, FR

Biotechnology has been recently seeing fundamental evolutions: first, a clear shift towards biological applications; second a trend towards the design and fabrication of portable devices; third the choice of inexpensive materials such as plastic or [...]

Recent advances in capillary microflows for point-of-care and home-care devices

Berthier J., Gosselin D., Huet M., Cubizolles M., Delapierre G., CEA/LETI/MINATEC, FR

Biotechnology has been recently seeing fundamental evolutions: first, a clear shift towards biological applications; second a trend towards the design and fabrication of portable devices; third the choice of inexpensive materials such as plastic or [...]

Reduction of the Hydrophobicity of Thiol-ene Microfluidic Devices Using an Adsorbed Polymeric Coating

Cretich M., Zilio C., Chiari M., Consiglio Nazionale delle Ricerche, IT

Thiol-ene based materials have gained a considerable interest in the field of micro and nano fluidics because of their physico-chemical properties and their polymerization characteristics. Unfortunately, the hydrophobic nature of this material represents a considerable [...]

Capture of circulating tumor cells (CTCs) using a novel micro-device

Ranjan S., Yong Z., National University of Singapore, SG

Circulating tumor cells (CTCs) are metastatic cells that are detached from a tumor and are found in the blood of cancer patients. The presence of CTCs in the blood indicates the metastatic stage of cancer, [...]

Effect of laser processing parameters and glass type on topology of micro-channels

Ben Azouz A., Brabazon D., Vázquez M., Macka M., Dublin City University, IE

Traditional techniques to manufacture micro-fluidic devices are well established but most are limited to surface micro-fabrication. Laser micro-machining provides an alternative technique for micro-fabrication of devices. This paper presents the fabrication of 3-D micro-channel structures [...]

Discrete Volume Controllable Microdispenser Module

Lee J., Lee S., Lee J., Lee S., Seoul National University, KR

We report a microdispenser that can meter and mix sub-nanoliter liquids in a discrete quantity. Our device is based on the structural stopping valve used in passive dispensers. A vent channel was proposed, designed for [...]

Fast and Sensitive DNA Hybridization Through Micro- Fluidics

Marafie A.H., Madou M.J., University of California Irvine, US

The research target for DNA hybridization through micro-fluidics is to achieve a fast and very sensitive hybridization reaction by investigating the effect of different pertinent parameters using computational and experimental methods. The mathematical model that [...]

Modeling the Fluid Dynamics of Electro-Wetting on Dielectric (EWOD)

Walker S., Shapiro B., University of Maryland, US

By applying voltages across a liquid droplet and an underlying dielectric, it is possible to make dielectric forces compete with surface tension forces, and to thereby cause the liquid droplet to change shape. This effect [...]

Application of Local Radial Basis Function-based Differential Quadrature Method in Micro Flows

Xu D., Ding H., Shu C., Agency for Science Technology and Research, SG

Numerical simulation of flows in micro geometry is one of the most appealing fields in computational fluid dynamics due to the advent of MEMS. In the present study, a local Radial Basis Function-based Differential Quadrature [...]

PCR Micro-Voume Device for Detection of Nucleic Acids

Auroux P-A, Day P., Niggli F., Manz A., Kinderspital, CH

The polymerase chain reaction (PCR) is an enzyme-mediated nucleic acid amplifer process that is employed extensively throughout the medical and biological sciences. The technique has risen to acclaim largely through its exquisite sensitivity, but an [...]