LNA – TechConnect Briefs

Novel Nanoprobes to Detect mRNA in situ Directed Against Mouse Pyruvate Dehydrogenas

Cheguru P., Østergaard M., Papasani M.R., Sai V.V.R., Wengel J., Hrdlicka P.J., Hill R.A., University of Idaho, US

Novel nanoscale synthetic locked nucleic acid (LNA) probes incorporating molecular beacon (MB) technology were developed. These novel MBs contained 2’-N-(pyren-1-yl)carbonyl-2’-amino-LNA monomers incorporated in the loop region. Specificity and sensitivity of MB designed to target the [...]

Development of Peptide Nucleic Acid Assemblies for Application in Drug Delivery and Molecular Sensing

Butler F.N., Elibol O., Hines B.D., Reddy Jr. B., Bashir R., Bergstrom D.E., Purdue University, US

We are exploring peptide nucleic acid (PNA) assemblies as interesting scaffolds for the fabrication of nanomaterials relevant to the diagnosis and treatment of disease. The first assembly is a PNA/LNA (locked nucleic acid) duplex employed [...]

An Investigation on Modeling and Statistical Simulation of Si-Ge Heterojunction Bipolar Transistors for Characterizing Their Dependence on Germanium Content

Sipahi L.B., Sanders T.J., Florida Institute of Technology, US

Although silicon is by far the most widely utilized manufactured semiconductor material, it is very poor in terms of mobilities of holes and electrons, which give rise to unacceptable low operation speeds. Far higher charge-carrier [...]