inflammation – TechConnect Briefs

Smaller sizes of Ag-PVP Nanoparticles Control Inflammatory Responses, and Reduce CD80 and CD86 Expression Levels, in Macrophages Infected with Chlamydia trachomatis

Yilma A.N., Singh S.R., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is an important cause of sexually transmitted infection that can manifest itself as either acute cervicitis, pelvic inflammatory disease, and more commonly as a chronic asymptomatic infection. Early intervention strategies that can reduce [...]

Inflammation and Cellular Toxicity Study of PAMAM Dendrimer Nanoparticles in Primary Isolated Human Lung Cells

Khan M.K., Kariapper M.S.T., Kasturirangan V., Lesniak W., Sharma M., Baumann H., Balogh L.P., Translational Research Scientist, US

Poly(amidoamine) (PAMAM) based dendrimers are a class of organic particulate nanomaterials with great promise for improvement in cancer imaging and therapy. In this study, we systematically modify terminal groups of the parent generation 5 primary [...]

The therapeutic effects of silver nanoparticle on the inflammatory disease of the temporomandibular joint

Kim A.S., Kim S-G, Kim A.S., Kim S-G, Lee A.R., Hallym Univerisity, KR

Purpose: The objective of this study was to exam the therapeutic effects of silver nanoparticle on the inflammatory disease of the temporomandibular joint in the animal model. Materials and Method: Mustard oil was injected to [...]

Potential anti-inflammatory properties of biologically-synthesized nanoparticles of gold or silver

Vercruysse K.P., Harper S.L., Ivory D.M., Whalen M.M., Saili K.S., Tanguay R.L., Tennessee State University, US

Ionic gold (Au) compounds have been used for many years in the treatment of rheumatoid arthritis (aurotherapy). Despite their long history, the basis for their therapeutic properties has never been established definitively. We have observed [...]

Oral Delivery of Map4K4 siRNA to Macrophages Inhibits TNF alpha Production and Protects against a LPS-Galactosamine Challenge in Mice

Aouadi M., Tesz G., Soto E., Wang M., Nicoloro S., Ostroff G., Czech M., University of Massachusetts Medical School, US

RNA interference (RNAi) is a new, promising approach to selectively regulate gene expression through modulating mRNA stability and translation. However, the efficient delivery of 21 mer dsRNA molecules (siRNA) to affect RNAi remains a challenge. [...]

Quantitative measurements of the strength of adhesion of human neutrophils to a substratum in a microfludic device: A novel inflammation diagnostic tool

Gutierrez E., Groisman A., University of California San Diego, US

We describe a quantitative assay of the strength of adhesion of activated and non-activated human neutrophils to a substratum, which is carried out in a custom-made microfluidic device. The strength of adhesion is quantified by [...]