drug delivery – Page 9 – TechConnect Briefs

Temperature-Triggered Nanotechnology for Chemotherapy: Rapid Release From Lysolipid Temperature-Sensitive Liposomes

Mills J.K., Needham D., Duke University; presently Sterne, Kessler, Goldstein & Fox, P.L.L.C., US

Despite advances in drug retention and evasion of the body’s defenses, the therapeutic efficacy of many liposomes has been limited by low drug bioavailability within the tumor. Developed in this laboratory in 1996, lysolipid temperature [...]

Recent Applications of Mesoscale Modeling to Nanotechnology and Drug Delivery

Maiti A., Wescott J., Kung P., Goldbeck-Wood G., Accelrys Inc., US

Technologically important nanomaterials come in all shapes and sizes. They can range from small molecules to complex composites and mixtures. Depending upon the spatial dimensions of the system and properties under investigation, computer modeling of [...]

Dimensioning of a New Micro-Needle for the Dispense of Drugs in Tumors and Cell Clusters

Berthier J., Rivera F., Caillat P., Berger F., CEA-LETI, FR

In medical treatment, there is a constant need to deliver active molecules into targeted cells, but this dispense is often difficult and time consuming. For example, in cancerology, it has been shown that active molecules [...]

Surface Modification Chemistries and their Utilization in Microarrays, Diagnostics and Drug Delivery

Lodhi M.A., Opperman G.W., Wall J.V., Anderson A.B., SurModics, Inc., US

Availability of DNA sequence data on numerous organisms has revolutionized the way biological queries are addressed today. Focus of activity has largely shifted from discovery to application. Things that were considered far-fetched only a few [...]

Protein Nanoparticles

Castor T.P., Aphios Corporation, US

Protein nanoparticles can be utilized for the pulmonary delivery of protein therapeutics or can be incorporated into biodegradable polymer microspheres/nanospheres for controlled release depot or oral delivery. With proteinaceous therapeutics, the generation of nanoparticles is [...]

Multi-scale Drug Release Modeling for Targeted Oral Drug Delivery (TODD)

Haddish B.N., Nyquist C., Haghighi K., Wu H.A., Corvalan C., Rickus J., Keshavarzian A., Purdue University, US

Conventional oral dosage forms deliver their active ingredient at rates that are high initially and decline afterward, showing a first order kinetics with the release determining step considered as the dissolution rate of the active [...]

New Highly Efficient Non-invasive Nanoparticulate Delivery Systems for the Treatment of Chronic Diseases

Sinner F.M., Institute of Medical Technologies and Health Management, Joanneum Research, AT

We herein report the overall goals of the joint project “Nano-Health” and preliminary results of two sub-projects (Nano-Health started in October 2004), which was positive evaluated by international reviewers within the first Call of the [...]

Superparamagnetic Iron Oxide Nanoparticles for Multiple Biomedical Applications

Hofmann H., Hofmann M., Petri-Fink A., Steitz B., von Rechenberg B., Hofmann H., Hofmann M., Juillerat J., Swiss Federal Institute of Technology Lausanne, CH

Superparamagneticiron oxide nanoparticles (SPION) were mixed at various ratios with different polymer solutions to obtain SPION coated with PVA modified by functional groups (amino-SPION, carboxy-SPION, and thiol-SPION). Studying human melanoma cells by theses different functionalized [...]

pH-Responsive Hydrogel with Controlled Swelling and Degradation Rate

Trujillo-Lemon M., Bowman C.N., Stansbury J.W., University of Colorado Denver and Health Sciences Center, US

Degradable polymeric materials that can be storage for months in aqueous enviroment before undergoing on-command controlled swelling and degradation were prepared and their kinetics of swelling and degradation were evaluated. The swelling and degradation rates [...]

Feasibility of Superparamagnetic Nanoparticles for Drug Delivery to the Inner Ear

Dormer K., Mamedova N., Kopke R., Liu J., Chen K., Gibson D., Jackson R., Costello M., Mondalek F., NanoBioMagnetics, Inc, US

An obstacle to effective treatment of inner ear diseases is the atraumatic delivery of therapeutics into inner ear perilymph. This study reports on the feasibility of using superparamagnetic nanoparticles as drug delivery vehicles.