cytokine – TechConnect Briefs

SiRNA for Therapeutic Immuno-modulation: Simultaneous Delivery of Cytokine-targeted SiRNA and DNA Antigens to Dendritic Cells using Polymer Microcarriers

Singh A., Nie H., Ghosn B., Roy K., The University of Texas at Austin, US

RNA interference mediated gene knockdown is a potential immuno-modulatory tool for tuning dendritic cells (DC) activation and function in-vivo. We have developed a novel multi-tiered delivery system for combinatorial administration of SiRNA and plasmid DNA [...]

Cytotoxicity of Nano-materials on Human Bronchial Epithelial Cell

Shin D.C., Jang J.Y., Yang J-Y, Kim C.S., Kim S-H, Choi I.H., Lim Y.W., Kim C.S., Kim S-H, Lee G.T., Yonsei University, KR

This study was undertaken to address the current deficient knowledge of cellular response to nano sized particle exposure.[4] The aim of this study was to investigate the in vitro responses of human bronchial epithelial cells [...]

Role of immunoregulators as possibility of tumor hypoxia-induced apoptosis

Sharma R., Kwon S., Chen C-J., Columbia University, US

IL-1, TNF-α and INF-γ cytokines stimulate in nitric oxide production and result with inflammation manifested by apoptosis and hypoxia. We propose that extent of inflammation leading to hypoxia initially and programmed cell death later both [...]

Ultramicro Protein Arrays for Cytokine Detection

Radke K., Ryckman K., Nettikadan S., Lynch M., Mosher C., Xu J., Henderson E., BioForce Nanosciences, Inc., US

Several solid phase microarray based methods for the detection of the genomic materials have been developed based on amplifying the target molecules. Since proteins cannot be amplified, a similar approach to protein detection faces some [...]

Functional Nanoarrays for Protein Biomarker Profiling

Lynch M., Mosher C., Huff J., Nettikadan S., Xu J., Henderson E., BioForce Nanosciences, Inc., US

The success of microarrays for analyzing nucleic acid and, more recently, protein-protein interactions illustrates the advantages of bioassay miniaturization. However, the current level of miniaturization of useful bioanalytical tools still creates limits in terms of [...]