Cytotoxicity of Nano-materials on Human Bronchial Epithelial Cell

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This study was undertaken to address the current deficient knowledge of cellular response to nano sized particle exposure.[4] The aim of this study was to investigate the in vitro responses of human bronchial epithelial cells (BEAS-2B) after exposure to nano-materials (Ag and CNT). BEAS-2B cell viability decreased with decreasing doses of Ag (diameters : 40~70 and 100 nm) and MWCNT (diameters : 4~6 and 10~15 nm) nano-materials. At the higher exposure ( 200 ug/ml), all materials induced significant cell damage. Nano Ag materials increased apoptosis and cytokine expression (IL-6 and IL-8) when over 100 ug/ml concentration. All MWCNTs weakly increased apoptosis and did not significantly increased cytokine expression. In conclusion, we suggest that Ag and MWCNT nano-materials induce variable extents of cellular toxicity in a dose-dependent and size-dependent.

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Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: June 1, 2008
Pages: 142 - 145
Industry sectors: Advanced Materials & Manufacturing | Personal & Home Care, Food & Agriculture
Topics: Environmental Health & Safety of Nanomaterials
ISBN: 978-1-4200-8504-4