chitosan – Page 2 – TechConnect Briefs

Chitosan-based nanomaterials for drug delivery and antibiotic-free bacterial control

Vila-Sanjurjo C., Fuenzalida J.P., Menchicchi B., Coelho D., Engwer C., Hoffman S., Pereira S., Remuñán-López C., Alonso M.J., Vidal A., Moerschbacher B., Kollenbrock S., Fetzner S., Philipp B., Goycoolea F.M., Westfaelische Wilhelms Universitaet - Muenster, DE

Research focused on chitosan (CS)-based nanostructured materials has burgeoned in the past decade or so, particularly in the biosciences and bionanotechnology fields. Chitosan characteristics (Mw and degree of acetylation), as well as the processing conditions [...]

Evaluation of F127 / chitosan hydrogel as a scaffold for bone repair

Yang M.-C., Lai W.-F., Taiwan University of Science & Technology/Taipei Medical University, TW

An in situ gelled scaffold for bone tissue engineering to restore the function of bone tissues is developed. The gel is comprised of Pluronic F127 and chitosan. The gelation temperature (Tgel), and viscoelastic properties and [...]

Supramolecular assemblies of cisplatin and polyelectrolytes: preparation, characterization and activity against cancer cells

Vieira D.B., Kim V., Petri D.F.S., Menck C.F.M., Carmona-Ribeiro A.M., Universidade de Sao Paulo, BR

Nanoformulation of cisplatin (Cis) is important to circumvent its high toxicity against normal cells. In this work, Cis cationic nanoparticles were prepared by the self-assembly of drug and oppositely charged polyelectrolytes (carboxymethylcellulose, CMC; chitosan, CH; [...]

Triple protection delivery system for retinaldehyde: Preparation, skin penetration and controlled release at the hair follicles

Supmuang P., Wanichwecharungruang S., Chulalongkorn University, TH

Vitamin A and its derivatives including retinaldehyde possess serious instability problem. To continuously supply skin with un-degraded retinaldehyde, nanoparticles which could penetrate into skin via hair follicles and then slowly release this vitamin A derivative [...]

Effect of Carbon Black and Silver Nanoparticle Loading on the Structural and Thermo-Mechanical Properties of Chitosan-Based Films

Blagg A., Perales-Perez O., Valentin R., University of Puerto Rico-Mayagüez, PR

This work addresses the synthesis and structural and thermo-mechanical characterization of bare and chitosan-based nanocomposite films synthesized via spin coating and sol casting techniques. The dependence of these properties as a function of the nature [...]

Stability of Functionalized Magnetic Particles in a Physiologic Fluid

Baca Ramos K., Martínez Pérez C.A., Camacho Montes H., Olivas Armendáriz I., Martel A., García-Casillas P.E., Universidad Autonoma de Ciudad Juarez, MX

Magnetic materials are widely used in biomedical applications such as magnetic separation, magnetic resonance imaging, drug delivery and hyperthermia. In these applications the nanoparticles are functionalized in a core/shell type with polymeric materials which contains [...]

Effects of Chitosan and Nanoparticles on Survival of Schwann Cells and Dorsal Root Ganglion Neurons

Lai J.C.K., Gao W., Leung S.W., Idaho State University, US

We have systematically examined the effects of chitosan film or chitosan in combination with nanometal particles (nanogold or nanosilver particles) on the growth of Schwann cells (S16) and DRG neurons (50 B 11). Results of [...]

Chitosan Membrane in Combinations with Nanoparticles and Adriamycin as a Treatment to Inhibit Glioma Growth and Migration

Leung S.W., Gao W., Gu H., Bhushan A., Lai J.C.K., Idaho State University, US

Our previous and on-going studies indicated that U87 cells cultured on chitosan film/membrane exhibited significantly slower growth and proliferation kinetics compared to U87 cells cultured in the absence of chitosan film/membrane. Chitosan exhibits anti-microbial activities [...]

Chitosan as mucoadhesive agent to enhance absorption of therapeutic proteins encapsulated into solid lipid nanoparticles

Teixeira J., Júlio A., Castro C., Fonseca J., Martins S., Ferreira D., Sarmento B., University of Porto, PT

The aim of this work was to develop Witepsol 85E solid lipid nanoparticles (SLN) containing insulin as biopharmaceutical, and to evaluate their potential for oral insulin administration. The new carrier was coated with chitosan in [...]

Evaluation of Nanoencapsulated DNA Vaccine for RSV

Boyoglu S., Vig K., Rangari V., Pillai S., Dennis V., Singh S.R., Alabama State University, US

Polymer nanoparticles have been used as carriers to enhance drug delivery. Among them chitosan is the most commonly used carrier, because it promotes long term of incorporated drugs. In the present study,we used DNA vaccine [...]