apoptosis – Page 2 – TechConnect Briefs

Cytotoxicity of Nano-materials on Human Bronchial Epithelial Cell

Shin D.C., Jang J.Y., Yang J-Y, Kim C.S., Kim S-H, Choi I.H., Lim Y.W., Kim C.S., Kim S-H, Lee G.T., Yonsei University, KR

This study was undertaken to address the current deficient knowledge of cellular response to nano sized particle exposure.[4] The aim of this study was to investigate the in vitro responses of human bronchial epithelial cells [...]

Cytotoxic Effects of Short Multi-wall Carbon Nanotubes

Agharkar V.A., Bhushan A., Lai J.C.K., Daniels C.K., Idaho State University, US

The applications of carbon nanotubes (CNTs), a novel and important class of nanomaterials, can change paradigms of various research areas. Although biomedical applications of CNTs are increasing, their putative cytotoxicity has not been substantially addressed. [...]

Nanotopography-controlled Cell Life and Death

Huang G.S., Su C-W, National Chiao Tung University, TW

NIH-3T3 cells were grown on nanodot arrays to investigate how cells respond to nanolandscape. The nanodot arrays consisted nanodot of diameters ranging from 10 to 200 nm which were fabricated by AAO processing on Ta-coated [...]

Modulation of Intracellular Ceramide using Polymeric Nanoparticles to Overcome Multidrug Resistance in Tumor Cells

van Vlerken L.E., Shenoy D., Duan Z., Seiden M., Mehta S., Amiji M.M., Northeastern University, US

This work describes the formulation of a nanoparticle drug delivery system to co-administer a chemotherapeutic, paclitaxel, and an MDR modulator, C6-ceramide, aimed at overcoming multidrug resistance (MDR) of solid tumors. MDR can arise through several [...]

Role of immunoregulators as possibility of tumor hypoxia-induced apoptosis

Sharma R., Kwon S., Chen C-J., Columbia University, US

IL-1, TNF-α and INF-γ cytokines stimulate in nitric oxide production and result with inflammation manifested by apoptosis and hypoxia. We propose that extent of inflammation leading to hypoxia initially and programmed cell death later both [...]

Apoptosis of the Human Neutrophils under a Lipopolisaccharide (LPS) of Proteus Mirabilis Condition Observed in Real Time by Atomic Force Microscopy (AFM)

Pleskova S.N., Guschina Yu., Zvonkova M.B., Medical State Academy Nizhniy Novgorod, RU

The goal of present work was to receive the images of apoptosis process in dynamics after addition of Proteus mirabilis 210 LPS and to measure the mechanical properties change of neutrophils’ membranes. We observed the [...]

Cellular Response to Nanoparticle Exposure

Erdos G.W., Moraga D., Palazuelos M., Powers K., University of Florida, US

Cells exposed to particles will phagocytose them and shuttle the endosomes to lysosomal compartments. Lysosomal mebranes rupture, possibly due to free radical formation. Proteases are released which inturn compromise the mitochondrial membranes. The mitochondria leak [...]