Alzheimer’s disease – TechConnect Briefs

TiO2 Nanowired Cerebrolysin reduces neuron-specific ubiquitin carboxyl-terminal esterase-L1 (UCHL1) in Alzheimer’s Disease and brain pathology

Muresanu D.F., Sharma A., Sharma H.S., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., University of Medicine & Pharmacy, RO

Our military personnel during combat operations are vulnerable to various kinds of traumatic brain injuries. These soldiers are prone to develop neurodegenerative diseases e.g., Alzheimer’s Disease (AD) over time. Thus, efforts should be made to [...]

Nanodelivery of Cerebrolsyin in combination with neprilysin induces neuroprotection in Alzheimer’s Disease pathology following brain injury

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Neprilysin (NPL) is an endogenous enzyme that functions as rate-limiting step in amyloid-beta peptide (AβP) degradation. There are reasons to believe that an imbalance between production and clearance of AβP results in its accumulation leading [...]

Nanomedicine in Neurodegenerative Disorders: understanding the journey

Tosi G., Ruozi B., Vilella A., Grabrucker A.M., Belletti D., Vandelli M.A., Boeckers T.M., Forni F., Zoli M., Sharma A., Sharma H.S., Muresanu D.F., Sharma A., Sharma H.S., Uppsala University, SE

The novelty of the last 3 years of research is on the fate of NPs made of poly-lactic-co-glycolic acid (PLGA) and engineered with g7, a glycopeptide that enhances BBB crossing capability, in the living mouse [...]

‘Sink effect’ of dually-decorated nanoliposomes on Abeta clearance

Re F., Minniti S., Bana L., Masserini M., Re F., University Milano Bicocca, IT

Plaques containing beta-amyloid peptides are one of the hallmarks of Alzheimer’s disease (AD) and the reduction of Abeta is considered a primary therapeutic target. Recently, strategies have been employed to reduce Abeta brain levels and [...]

NAD-Nanoparticles for Therapy and Diagnosis of Alzheimer Disease

Masserini M., Gregori M., Salvati E., Re F., Masserini M., University Milano Bicocca, IT

NAD project (large cooperative; 19 partners, funded by the E.C.) is aiming to the therapy and diagnosis, even combined, of Alzheimer Disease, by synthesis of multiple-functionalized nanoparticles, able to bind, detect and remove Abeta from [...]

Development of a high sensitivity fluorescence immunoassay for Amyloid Beta 42 by a silicon microarray platform

Cretich M., Gagni P., Chiari M., Consiglio Nazionale delle Ricerche, IT

Alzheimer’s disease (AD) affects millions of people around the world with rising incidence as population age. Here we present the use of a label/label free silicon/silicon oxide (Si/SiO2) based microarray platform to develop a highly [...]

Filamentous Bacterial Viruses Break Down Amyloid Plaques in an Animal Model of Alzheimer’s Disease – A Novel Therapeutic Avenue

Solomon B., Tel Aviv University, IL

We present here results suggesting that intranasal administration of wild type M13 bacteriophage may serve as a safe alternative to immunotherapy to disaggregate existing amyloid plaques and prevent formation of new ones, countering the neurodegeneration [...]