AFM – Page 7 – TechConnect Briefs

Dip Pen Nanolithography®: A Maturing Technology for High-Throughput Flexible Nanopatterning

Haaheim J.R., Tevaarwerk E.R., Fragala J., Shile R., NanoInk Inc, US

Precision nanoscale deposition is a fundamental requirement for much of current nanoscience research. Further, depositing a wide range of materials as nanoscale features onto diverse surfaces is a challenging requirement for nanoscale processing systems. As [...]

Nanogaps for fabrication of Molecular Devices

Kabir M.S., Enokson P., Chalmers University of Technology, SE

The development of different alternative technologies to fabricate various types of nanoscale devices based on non-conventional materials such as molecules and clusters are here reported. We had two different approaches to fabricate nangaps though there [...]

Large scale synthesis of ordered silver nanoparticles for superhydrophobic and anti-icing application

Safaee A., Sarkar D.K., Farzaneh M., Université du Québec à Chicoutimi, CA

Large scale syntheses of ordered colloidal silver nanoparticles have been achieved through solution phase method. These colloidal nanoparticles have been spin-coated on glass substrates and investigated using AFM and UV-Vis spectroscopy. Nearly cubic shape silver [...]

Characterisation of Drug Nanoparticles by Atomic Force Microscopy

Bailey N.A., Booth J., Clark B.C., AstraZeneca, UK

A key consideration when developing a drug nanoparticle formulation, particularly when intended for parenteral administration, is the control of particle size, shape and physical properties such as dissolution rate and stability with respect to Ostwald [...]

Detection and Localization of Antibody-Antigen Interactions with High Spatial Resolution on Collagen Tendons

Boyd R.D., Avci R., Schweitzer M., Wittmeyer J., Spangler B., Thieltges K.M., Cranfield University, UK

Measuring ligand receptor forces using the atomic force microscope as a force-sensing instrument has been well documented. For example in the detection of antibody-antigen interactions with the antibody attached to the AFM tip with a [...]

Mounting proteins on metal nanoparticles: Statistical analysis of AFM images

Gurevich L., Fojan P., Saxena R.K., Petersen S.B., Aalborg University, DK

In this work we assess the use of atomic force microscopy (AFM) study combined with activity assays, DLS and fluorescent measurements for complex characterization of nanoparticle-protein conjugates. Image processing techniques were used to locate and [...]

Sensing and Plotting Single Molecule Binding Events with the Atomic Force Microscope

Johnson W.T., Molecular Imaging, US

SPM/AFM (scanning probe microscopy/atomic force microscopy) offers many unique advantages to the study of biological process at the nanometer scale. ASM/AFM allows scientists to visualize, probe, and analyze the structure of biological molecules in their [...]

Assembly of DNA Rotaxanes for AFM Based DNA Sequencing

Spadola Q., Qamar S., Lin L., Lindsay S.M., Ashcroft B., Zhang P., Lindsay S.M., The Biodesign Institute at Arizona State University, US

The desire to sequence DNA is fueled by the knowledge that the information locked inside of genomes can help fields as varied as molecular medicine, bioarcheology, forensics, and environmental science. The challenge is to establish [...]

Nanoscale Analysis of Bone Mineral Crystals

Chen H., Robinson C., Shore R.C., Brookes S.J., Zhang J., Smith D.A., Clarkson B.H., Kirkham J., University of Michigan, US

The mineral component of both bones and teeth comprises of crystals of calcium hydroxyapatite. However, there are very few studies which have characterised and compared individual crystals from these mineralised tissues at the nanoscale. In [...]

The Relationship Between Nanoscale AFM Adhesive Force Measurements using Calcite Crystals with Macroscale contact angle and Scaling Characteristics

Boyd R.D., Bargir S., Dunn S., Jefferson B., Cranfield University, UK

The growth of scale, which primarily consists of calcite crystals, is a major problem in water systems. AFM probes have been modified with calcite crystal in order to measure the strength of adhesion between the [...]