Singh S.R. – Page 2 – TechConnect Briefs

Peptide RF482 Encapsulated Chitosan – PLGA Nanoparticles Inhibit Respiratory Syncytial Virus

Bawage S.S., Tiwari P.M., Dennis V.A., Singh S.R., Alabama State University, US

Worldwide, human respiratory syncytial virus (RSV) is one of the leading causes of lower respiratory tract infections in children and older adults. Currently, an anti-viral drug ribavirin and RSV neutralizing monoclonal antibody- palivizumab are the [...]

Influence of Polyvinyl Alcohol (PVA) on Morphology and Encapsulation Efficiency of Polylactic Acid-Polyethylene Glycol (PLA-PEG) copolymer based Nanoparticle’s

Dixit S., Davis M.D., Singh S.R., Dennis V.A., Alabama State University, US

Polyvinyl alcohol is the most commonly used emulsifier in the formulation of NPs. Provides non-aggregating, emulsifying and adhesive properties to NPs and an interconnected network with the polymer at the interface which ultimately can affect [...]

Silver coated carbon nanotubes regulate virulence gene expression in Salmonella Typhimurium

Chaudhari A.A., Singh S.R., Pillai S., Alabama State University, US

Silver coated carbon nanotubes (AgCNTs) have several biomedical applications and their antibacterial activity against several multi drug resistant pathogens is well documented. However, the exact molecular mechanism for their antibacterial activity is yet to be [...]

Activation of antigen presenting cells and induction of mucosal antibodies by Chlamydia trachomatis outer membrane peptide encapsulated within PLA-PEG nanoparticles

Dixit S., Taha M., Singh S.R., Dennis V.A., Alabama State University, US

In pursuit of a vaccine against Chlamydia trachomatis, the most reported bacterial sexually transmitted infection, we previously reported that encapsulation of M278, a peptide derived from the major outer protein of C. trachomatis within PLA-PEG [...]

Reduced bacterial attachment on surface modified hydrophobic fabric surface: a possible approach for safety enhanced packaging material

Chaudhari A.A., Rangan K.K., Sudarshan T.S., Singh S.R., Pillai S.R., Alabama State University, US

In the present study, three surface modified fabrics were investigated for their bacterial attachment properties using Salmonella enterica serovar Typhimurium (gram –ve) and Staphylococcus aureus (gram+ve) bacteria. Our results indicate that surface modified fabric show [...]

Characterization of silver-coated carbon nanotubes dispersed in a specifically formulated dispersant – NanoSperse AQ®

Chaudhari A.A., Singh S.R., Pillai S.R., Alabama State University, US

Silver-coated carbon nanotubes (AgCNTs) are well documented for their antibacterial properties. However, aqueous dispersions of AgCNTs could be less effective against bacteria due to their tendency to agglomerate when re-suspended in water. In this study [...]

Superparamagnetic Iron Oxide Nanoparticles as Drug Delivery Vehicles

Vig K., Casey K., Tiwari P.M., Miller M., Samant R., Singh S.R., Alabama State University, US

In recent years, nanotechnology has emerged as one of the most promising fields for biomedical applications and healthcare. The use of nanoparticles has earned much attention due to their small size, high surface area to [...]

Poly-Vinyl Pyrrolidone (PVP)-coated Silver (Ag) Nanoparticles (Ag-PVP): a Potential to Regulate Chlamydia trachomatis Inflammation

Yilma A.N., Singh S.R., Dixit S., Hidat G.G., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is an important cause of sexually transmitted infection that can manifest itself as either acute cervicitis, pelvic inflammatory disease, and more commonly as a chronic asymptomatic infection. Previously we reported Ag-PVP (5-10 nm) [...]

Mechanism and Free Energy of DNA Hybridization on Single-Walled Carbon Nanotubes Using Adaptive Biasing Force Simulations

Chien M.W., Johnson Jr. A.T.C., Johnson R.R., Pillai S., Singh S.R., Johnson Jr. A.T.C., Johnson R.R., University of Pennsylvania, US

DNA-carbon nanotube hybrids (DNA-NT) consist of single stranded DNA self-assembled to the sidewall of single-walled carbon nanotubes. DNA-NT show great promise for applications in nanotechnology, including chemical sensing and sequence-specific DNA detection. Details of the [...]

PLA-PEG as a delivery system for a Chlamydia trachomatis subunit vaccine

Dixit S., Singh S.R., Yilma A.N., Agee R., Dennis V.A., Alabama State University, US

We hypothesize that M287 encapsulated in PLA-PEG will provide for its slow controlled release and thus enhance its capacity to induce immune responses in mice.