Motte L. – TechConnect Briefs

Nano-Organocatalysts: new magnetically retrievable tools for enantioselective synthesis

Nehlig E., Motte L., Guénin E., Université Paris, FR

We report the elaboration of new organocatalyst functionalized superparamagnetic iron oxide nanoparticles that can act as a new enantioselective organocatalyst. Differents organocatalysts are grafted using two different methodologies on a nanoplateform constituted of 10 nm [...]

Nano-Organocatalysts: new magnetically retrievable tools for enantioselective synthesis

Nehlig E., Motte L., Guénin E., Université Paris, FR

We report the elaboration of new organocatalyst functionalized superparamagnetic iron oxide nanoparticles that can act as a new enantioselective organocatalyst. Differents organocatalysts are grafted using two different methodologies on a nanoplateform constituted of 10 nm [...]

Microwave irradiation and Click chemistry for highly efficient and chemoselective multivalent iron oxide nanoparticle surface modification

Guénin E., Nehlig E., Demay Drouard P., Benyettou F., Motte L., Université Paris, FR

Magnetic nanoparticles (mNPs) are attractive candidates for numerous applications due to their unique properties. For all these applications mNPs surfaces must be tailored to improve biocompatibility properties or reduce aggregation but also to insert molecules [...]

New Multimodal Iron Oxide Nanoparticles as Nanotools for Cancer

Benyettou F., Chebbi I., Lalatonne Y., Sainte-Catherine O., Di Benedetto M., Lecouvey M., Seksek O., Motte L., Université Paris 13, FR

The goal of this project is to elaborate new multifunctional magnetic nanovectors to vectorize biological interest molecules for therapy and diagnostic applications. Indeed, iron oxide nanoparticles, tanks to their magnetic properties, are used as contrast [...]

Innovative Nanoprobes for Multiparametric Magnetic Immunoassays: Elaboration and Characterization

Brioude A., de Beaucorps C., Alphandéry E., Benyettou F., Brioude A., Bonnin D., Weinmann P., Motte L., Lalatonne Y., Avicenne Hôspital, FR

Magnetic nanoparticles (MNPs) are commonly used for contrast enhancement in magnetic resonance imaging, as magnetic carriers in automated immunoassays instruments, or for cell concentration at the bench. They are being evaluated all over the world [...]

Anticancer Iron Oxide Nanoparticles

Benyettou F., Lalatonne Y., Sainte-Catherine O., Lecouvey M., Motte L., Laboratoire CSPBAT FRE 3043 CNRS, FR

We designed a new therapeutic nanoplatform which could be both imaged in situ with MRI (T2 contrast agent) and/or addressed by magnetic targeting (magnet) or specific molecules (peptides, antibodies …). The biological in-vitro tests performed [...]