Marche P.N. – TechConnect Briefs

Nanostructured Lipid Carriers to Deliver HIV p24 Antigen and CpG Immunostimulant in Mice and Non-Human Primates Immunogenicity Studies

Bayon E., Morlieras J., Gosse L., Gonon A., Bosquet N., Le Grand R., Marche P.N., Navarro F.P., CEA-LETI, FR

Fighting HIV pandemic is one of today’s major health priorities and vaccination remains the most challenging issue against HIV propagation. Until now, the best vaccine candidate showed only 30% protection in RV144 clinical trial [1]. [...]

Lipid nanoparticles for enhancing immune responses to protein antigens

Courant T., Reynaud H.L., Hoang A., Villiers C., Mittler F., Texier I., Marche P.N., Navarro F.P., CEA/LETI/MINATEC, FR

In the near future, novel vaccines will be needed, particularly nanoparticles-based vaccine formulations for figthing problematic infectious diseases like tuberculosis, AIDS/ HIV or malaria and also cancers. Here, we described the development of versatile chemical [...]