Huang G.S. – TechConnect Briefs

Gold nanoparticles caused learning impairment in mice

Chen Y-S, Hung Y.-C., Liau I., Lin L.-W., Hong M.-Y., Huang G.S., National Chiao Tung University, TW

Aims : To investigate the toxic effect of gold nanoparticles (GNP) to the learning and memory of mice. Key findings: Both 17 nm and 37 nm GNPs induced severe sickness in mice. However, only 17 [...]

Nanoparticle-enhanced Magnetic Field Induces Apoptosis in Nematode

Huang G.S., Yeh L.K., Chen Y-C, National Chiao Tung University, TW

To investigate molecular consequence of magnetic field to C. elegans, Fe3O4 nanoparticles were incorporated into the culture media of C. elegans and the nematodes were grown under magnetic field for 4 days. For the expermental [...]

Nanotopography-controlled Cell Life and Death

Huang G.S., Su C-W, National Chiao Tung University, TW

NIH-3T3 cells were grown on nanodot arrays to investigate how cells respond to nanolandscape. The nanodot arrays consisted nanodot of diameters ranging from 10 to 200 nm which were fabricated by AAO processing on Ta-coated [...]

Differential lethality of gold nanoparticles is associated with immunogenecity

Huang G.S., Chen Y-S, Yeh H-W, National Chiao Tung University, TW

To obtain antibodies specifically recognizing gold nanoparticles (GNPs) BALB/C mice were immunized by weekly intra-peritoneal injection of adjuvant-emulsified 5 nm, 8 nm, 12 nm, 17 nm, and 37 nm GNPs. Mice injected with 8 nm, [...]

Application of Quantum dots for the lifespan study of Caenorhabditis elegans

Huang G.S., Chang K-M, Chen Y-C, Yeh L-G, National Chiao Tung University, TW

The progress in identifying drugs that extend lifespan of Caenorhabditis elegans has been slow partly due to the tedious and labor-intensive nature of drug screening. We labeled C. elegans by mixing quantum dots, FITC, or [...]