Caillat P. – TechConnect Briefs

A Model for Enhanced Chemiluminescence Reactions in Microsystems

Berthier J., Joly P., Rivera F., Caillat P., CEA-LETI, FR

Detection of hybridized targets—like DNA strands—in microsystems for biotechnology is usually done by fluorescence. However, recent investigations have shown that chemiluminescence could be a more effective and sensitive tool for detection under the condition that [...]

The Physics of Pressure Powered Micro-Flow Focusing Device for the Encapsulation of Live Cells

Berthier J., Dalle P., Rivera F., Renaudot R., Morales S., Benhamou P-Y., Caillat P., CEA-LETI, FR

Flow focusing devices (FFD) have emerged as a powerful tool for cell encapsulation and formation of micro-emulsions [1,2]. In the frame of live cell encapsulation, a micro-FFD using alginate solutions for the capsule and powered [...]

On the behavior of non-Newtonian fluids in microsystems for biotechnology

Berthier J., Le Vot S., Tiquet P., Rivera F., Caillat P., CEA/LETI/MINATEC, FR

In Biotechnology, it is generally the use to calculate and design prototypes of microsystems by considering aqueous or organic liquids that have a spatially uniform viscosity. However, many liquids used in biological applications are at [...]

Specific device for cells sampling

Cosnier M.L., Martin F., Ratel D., Berger F., Caillat P., Commissariat à l’Energie Atomique, FR

We developed a miniaturized biopsy tool for harvesting molecules of interest in delicate areas such as brain. This tool permits harvesting of intact cells permitting genomic analysis on these cells. The sampling tool is manufactured [...]

Development of a specific micro/nanodevice validating the concept of molecular biopsy

Berger F., Bouamrani A., Cosnier M., Martin F., Caillat P., Benabid A.L., Inserm, FR

The nanomedicine concept implies early detection at the molecular level and molecular characterisation to implement a specific therapy. In this context, the development of micro/nanotool devoted for intra-tissular characterisation is indispensable. We first demonstrated that [...]

Dimensioning of a New Micro-Needle for the Dispense of Drugs in Tumors and Cell Clusters

Berthier J., Rivera F., Caillat P., Berger F., CEA-LETI, FR

In medical treatment, there is a constant need to deliver active molecules into targeted cells, but this dispense is often difficult and time consuming. For example, in cancerology, it has been shown that active molecules [...]

Numerical Modeling of Diffusion in Extracellular Space of Biological Cell Clusters and Tumors

Berthier J., Rivera F., Caillat P., CEA-LETI, FR

Biological cluster of cells may be seen as porous media, where the cells are the “solid grains” and the extracellular space (ECS) the “pores”. It is often the case in dense clusters of cells that [...]