Auburn University – Page 2 – TechConnect Briefs

CFD-Assisted Design and Optimization of a Pharmacokinetic Microfluidic System

Moeini Sedeh M., Khodadadi J.M., Hong J.W., Cramer K.A., Hamon M., Auburn University, US

In this research, a microfluidic system was designed and optimized to carry out in vitro pharmacokinetic studies of drug candidates in the liver. Computational fluid dynamics (CFD) was called on to assist in the system [...]

Numerical Simulation of the Solidification of Water-Based Nanofluid

El Hasadi Y.M.F., Khodadadi J.M., Auburn University, US

Nanofluids are colloidal suspensions which they consist particles in the size range of 100-1 nm. In the recent years nanofluids kept the attention of the scientific community due to their improved thermal physical properties compared [...]

Prediction of Thermal Conductivity of Liquid Methane/Ethane-Cu Nanofluids via Molecular Dynamics Simulations

Babaei H., Khodadadi J.M., Auburn University, US

The improvement of thermal conductivity by suspending nanoparticles in two hydrocarbon-based nanofluids is investigated by means of molecular dynamics simulations. Base fluids are methane and ethane and nanoparticles are pure copper. Two temperatures for which [...]

An Experimental Determination of Temperature-Dependent Thermal Conductivity of Cyclohexane-Based Nanofluids

Fan L., Khodadadi J.M., Auburn University, US

In extending their applicability , utilization of nanofluids as superior solid-liquid phase change materials (PCM) for thermal energy storage has been proposed recently. This extension of potential utility of nanofluids will require thermal conductivity measurements [...]

Optimization of Phage-Based Magnetoelastic Biosensor Performance

Huang S., Yang H., Johnson M., Wan J., Chen I., Petrenko V.A., Chin B.A., Auburn University, US

A magnetoelastic (ME) platform coated with a bio-molecular recognition element (bacteriophage) for selective and specific recognition of Bacillus anthracis spores is described. ME materials have a mass-sensitive, characteristic, resonant frequency. In response to the binding [...]

Optimization of Phage-Based Magnetoelastic Biosensor Performance

Huang S., Yang H., Johnson M., Wan J., Chen I., Petrenko V.A., Chin B.A., Auburn University, US

A magnetoelastic (ME) platform coated with a bio-molecular recognition element (bacteriophage) for selective and specific recognition of Bacillus anthracis spores is described. ME materials have a mass-sensitive, characteristic, resonant frequency. In response to the binding [...]

Landscape Phage Probes for Breast Cancer Cells

Fagbohun O.A., Bedi D., Jayanna P.K., Deinnocentes P.A., Bird R.C., Petrenko V.A., Auburn University, US

Landscape phage libraries are collections of filamentous phages displaying random foreign peptides on all 4,000 surface domains of the major coat protein. They serve as a rich source of bioselective materials that are used in [...]

Landscape phage probes for PC3 prostate carcinoma cells

Jayanna P.K., Deinnocentes P., Bird R.C., Petrenko V.A., Auburn University, US

Cancer chemotherapy is complicated by a lack of selective drug targets. The use of liposomes as vectors for drug delivery has provided a route to selective accumulation of nanoparticles in the tumor interstitium due to [...]

Landscape phage libraries as a source of bioselective nanomaterials

Kuzmicheva G.A., Sorokulova I.B., Jayanna P.K., Petrenko V.A., Auburn University, US

New generations of targeted diagnostic, therapeutic and imaging nanodevices require robust molecular recognition interfaces, which bind their targets with high specificity and selectivity. These bioselective interfaces can be formed by recombinant filamentous phages or their [...]

Modulating affinity of landscape phage nanoparticles by mutagenesis of the major coat protein

Kuzmicheva G.A., Eroshkin A.M., Potemkin V.A., Petrenko V.A., Auburn University, US

Phage peptide libraries proved to be invaluable source of the ligands specifically binding numerous analytes. Diversity and repertoir of the libraries are critical for the successful selection of ligands. In landscape libraries guest peptides are [...]