US – Page 95 – TechConnect Briefs

Collective Behavior of an Array of Spin Torque Nano-Oscillators

Buono P.L., Dabrowski C., Palacios A., Turtle J., In V., San Diego State University, US

As predicted by Slonczewski and Berger, a spin-polarized current can exert a torque on the magnetization of a ferromagnetic layer leading to precession. Then the Giant Magnetoresistance Effect (GMR) can convert the magnetic precession into [...]

Molecular Dynamics Simulations of Polytetrafluoroethylene at Glassy Transition Temperature

Al-Nsour R., Virginia Commonwealth University, US

This research is concerned with studying and understanding the thermal and mechanical behavior of PTFE. Such understanding is critical to predicting PTFE behavior and allowing bottom up design of improved polymers for specific applications. While [...]

Investigating Modified Oligonucleotides as Robust, Programmable Release Agents

Tohver Milam V., Eze N., Georgia Institute of Technology, US

While LNA has been examined as a therapeutic agent in various antisense scenarios, we are exploring LNA as a programmable biomaterials assembly and disassembly tool under isothermal conditions. To drive isothermal disassembly of LNA-linked objects, [...]

β3 Integrin siRNA-Loaded Multifunctional Nanoparticle Therapy for Metastatic Breast Cancer

Gujrati M., Parvani J.G., Schiemann W.P., Lu Z.R., Case Western Reserve University, US

Successful siRNA-mediated cancer therapy requires the use of multifunctional nanoparticle systems to overcome the barriers associated with delivery. We have recently developed a cationic lipid-based carrier, ECO, which efficiently delivers siRNA intracellularly to induce potent [...]

Activation of antigen presenting cells and induction of mucosal antibodies by Chlamydia trachomatis outer membrane peptide encapsulated within PLA-PEG nanoparticles

Dixit S., Taha M., Singh S.R., Dennis V.A., Alabama State University, US

In pursuit of a vaccine against Chlamydia trachomatis, the most reported bacterial sexually transmitted infection, we previously reported that encapsulation of M278, a peptide derived from the major outer protein of C. trachomatis within PLA-PEG [...]

Synthesis and evaluation of T85-LPEI copolymers for pDNA delivery

Wang M.X., Carolinas Medical Center, US

In this study, a series of low molecular weight PEI (LPEI) modified with Tween 85 were prepared by varying feed ratio and PEI size (Mw: 0.8k, 1.2k and 2.0k Da) for gene delivery. The Mws [...]

Applying Plasmon Resonant Coating to Commercial Liposomal Delivery Systems

Knights-Mitchell S.S., University of Arizona, US

Multiple drug-encapsulated liposomes have been successfully marketed as pharmaceuticals within the past two decades. Some of these liposomal drugs have been shown to selectively localize within tumors. However, one limitation is the inability to control [...]

How does nanoparticle design affect targeting selectivity: computer modeling

Dormidontova E.E., University of Connecticut, US

One of the areas of active development of modern nanomedicine is application of polymer tethered nanoparticles for drug/gene delivery and imaging. The optimal nanoparticle design for targeting one type of cell may be quite different [...]

Preparation and characterization of starch nanoparticles by desolvation method

Uzun S., Kokini J.L., University of Illinois, US

Nanoparticles prepared from biocompatible and biodegradable materials have attracted considerable attention in food and pharmaceutical science. Starch is one of abundant biopolymer. In this study, starch nanoparticles were produced by desolvation method and the influence [...]

Chemiresistive hydrogen (H2) gas sensor based on viral-templated Pd nanowires

Moon C.H., Yan Y., Zhang M., Myung N.V., Haberer E.D., University of California Riverside, US

Palladium (Pd) has been widely used for H2 sensing applications because it readily forms a solid solution with hydrogen, modifying electrical resistance. Because the resistance change is diffusion-limited, Pd nanostructured materials with large surface area [...]