US – Page 70 – TechConnect Briefs

Sensing voltage change across a lipid bilayer

Chen Y., Makinen A.J., O’Shaughnessy T.J., Efros A.L., Huston A., Susumu K., Stewart M.H., Delehanty J.B., Naval Research Laboratory, US

Developing nanoscale probes capable of real-time sensing and imaging of neuronal action potentials would be useful in understanding neuronal communication. However, current available tools for imaging action potentials lack either the spatial or temporal sensitivity [...]

From Nanogenomics and Structural-Functional Proteomics to Personalized Medicine for Oral Lichen Planus (OLP) as a Translational Model of Oral Cancer Usefull to Introduce an Industrial Technical Innovation

Nicolini C., Peshkova E., Bragazzi N., Fondazione ELBA Nicolini, US

Oral Lichen Planus (OLP) is a common chronic inflammatory disease, which involves the mucous membranes of the oral cavity, with an overall age-standardized prevalence of 1.27% (0.96% in men and 1.57% in women) as reported [...]

Microarray based Functional Nanoproteomics and Cancer

Nicolini C., Peshkova E., Fondazione ELBA Nicolini, US

Using NEBL proprietary “SNAP based Genes Expression” in conjuction with our proprietary “Submicron Arrays” (Anodic Porous Allumina and/or Kapton based Nanopores) , we use proprietary DNASER and Label Free Nanotechnologies to carry out : 1_Construction [...]

A Multifunctional Theranostic Nanoplatform for Image-Guided Surgery and Intraoperative Therapy

Taratula O., Schumann C., Duong T., Taylor K.L., Taratula O., Oregon State University, US

Currently, only optimal surgical resection of all disease sites can improve survival of ovarian cancer patients. Even with the best microsurgical techniques, however, palpation and visual inspection for malignant tissue identification can result in microscopic [...]

Mitochondria-targeting Gold Nanoparticles for Improved Therapeutic Efficacy of Photodynamic Therapy of Breast Cancer

Yang Y., Gao N., Hu Y., Jia C., Du H., Wang H., Stevens Institute of Technology, US

Photodynamic therapy (PDT) is an emerging minimally invasive therapeutic modality for a variety of oncologic diseases. In recognition of their superior optical and surface plasmonic properties, gold nanoparticles (Au NPs) can be utilized as the [...]

Oxidized Graphene Nanoribbons as a Delivery System for the Bioactive Sphingolipid Ceramide

Suhrland C., Truman J.P., Sitharaman B., Stony Brook University, US

Dysregulation of the metabolic pathways of the sphingolipid ceramide has been shown to play key roles in cancer cell proliferation and survival. Targeting these pathways with exogenous modulators of ceramide metabolism such as the short [...]

Dielectrophoretic Isolation and Detection of Cancer Related DNA and RNA Nanoparticulate Biomarkers from Blood and Plasma

Heller M.J., Marciniak J., Skowronski E., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA and RNA nanoparticulate biomarkers continues to become more widely used for cancer diagnostics and management. Generally, cfc-DNA for “liquid biopsies” is isolated form plasma using relatively long [...]

A New and versatile method for preparing crystalline drug nanoparticle formulations

Higgins J.D., Merck Research Labs, US

The birth of the nanoparticle (nanos) drug delivery field arguably was seen over 20 years ago with the advent and application of simple oral crystalline nanoparticle formulations. This effective approach for enhancind oral absorption using [...]

Co-Culturing Dorsal Root Ganglion Neurons with Schwann Cells Protects Them Against the Cytotoxic Effects of Silver Nanoparticles

Gao W., Leung S.W., Bhushan A., Lai J.C.K., Idaho State University College of Pharmacy, US

Because of their presumed inertness, silver nanoparticles are increasing employed in many consumer products. Nonetheless, their environmental and health hazard impact are not understood. Our previous studies led us to develop a co-culture model consisting [...]

Schwann Cells and Dorsal Root Ganglion Neurons Are Differentially Susceptible to Oxidative Stress Induced by Silicon Dioxide Nanoparticles

Lai J.C.K., Jaiswal A.R., Idikuda V.K., Pfau J., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Silicon dioxide (SiO2) particles, including nanoparticles, have been increasing employed in diverse industrial and biomedical applications including those in drug formulations, food, and cosmetics as SiO2 has been generally regarded as a non-toxic substance. However, [...]