US – Page 172 – TechConnect Briefs

The Intracellular Co- localizations of Different Size of Gold Nanoparticles

Boyoglu C., Boyoglu-Barnum S., Boyoglu-Barnum S., Soni S., He Q., Willing G., Miller M.E., Singh S.R., Alabama State University, US

Gold nanoparticles (GNPs) are widely used in biological and clinical applications due to their favorable optical and chemical properties. The scientific understanding of the intracellular uptake of GNP is required for biomedical applications, such as [...]

New in Vitro Strategy of Astrocytoma (Astrocytes-like) Cells Treated with Pioglitazone ( PPAR gamma agoinst) Offers Neuroprotection Against Nanoparticle-Induced Cytotoxity

Wong Y.Y.W., Jaiswal A., Dukhande V.V., Bhushan A., Leung S.W., Lai J.C.K., Idaho State University, US

Recently, we and others have developed several cell models for the investigation of the molecular mechanisms underlying the cytotoxicity of nanoparticles of several metallic and non-metallic oxides. These important findings have raised the awareness for [...]

Cerium Oxide Nanoparticles Protect Against MPTP-Induced Dopaminergic Neurodegeneration in a Mouse Model for Parkinson’s Disease

Dillon C.D., Billings M., Hockey K.S., DeLaGarza L., Rzigalinski B.A., Virginia College of Osteopathic Medicine, US

In this abstract, we demonstrate that cerium oxide nanoparticles protect against neurodegeneration in a mouse model of Parkinson’s Disease.

Evidence of the Anti-inflammatory effect of Silver- polyvinyl Pyrrolidone Nanoparticles (Ag-PVP) in Chlamydia trachomatis infected Macrophages and HeLa Cells

Yilma A.N., Singh S.R., Murtada T.A., Fairley S., Subbarayan P., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is the leading cause of bacterial sexually transmitted diseases (STDs) in the USA, and therefore, of major public health significance. C. trachomatis invades the mucosal surface of the female genital tract consequently triggering [...]

Quantum Dots as a Unique Nanoscaffold to Mimic Membrane Receptor Clustering

Anikeeva N., Gakamsky D., Sykulev Yu., Thomas Jefferson University, US

We utilized quantum dots (QD) as a unique nanoscaffold with uniform size and well-defined structure to assemble membrane immune receptors on the surface of the dots at desired density. Such QD/receptor biosensors appear to be [...]

Effects of Chitosan and Nanoparticles on Survival of Schwann Cells and Dorsal Root Ganglion Neurons

Lai J.C.K., Gao W., Leung S.W., Idaho State University, US

We have systematically examined the effects of chitosan film or chitosan in combination with nanometal particles (nanogold or nanosilver particles) on the growth of Schwann cells (S16) and DRG neurons (50 B 11). Results of [...]

The mechanical sensitivity of vesicle dynamics in in vivo and in vitro neurons

Ahmed W., Li T., Rubakhin S., Chiba A., Sweedler J., Saif T.A., University of Illinois at Urbana-Champaign, US

To study the mechanical response of both in vivo and in vitro neurons, we have developed a novel platform for in-situ high-resolution live-imaging of cells and tissues under applied mechanical strain. The system is capable [...]

Cytotoxic studies of PEG functionalized ZnO Nanoparticles on MCF-7 cancer cells

Rodriguez Martinez C., Ramirez Vick J.E., Perales O., Singh S.P., University of Puerto Rico-Mayagüez, US

Nanoparticles have shown great promise in biomedical applications. Zinc oxide (ZnO) nanoparticles are being explored for various applications such as sun screen lotion, antimicrobial properties, advanced textiles, photodynamic therapy and electronic devices. We have synthesized [...]

Folate-Conjugated Gold Nanoparticles for Cancer Nanotechnology Applications

Brandenburg K.S., Shakeri-Zadeh A., Mansoori G.A., University of Illinois at Chicago, US

A need exists to target cancer treatments specifically to the tumor site, without damaging healthy tissue. This need can be achieved through the proper application of nanotechnology, namely gold nanoparticles conjugated to Folate. Folate is [...]

Prostate Cancer-Specific Drug Delivery and Imaging System: Design, Synthesis, and Characterization of Multi-functional AuNPs

Dao K-L, Northeastern University, US

A multifunctional gold nanoparticulate (mfAuNPs) drug delivery system that is specific for prostate cancer therapy will be presented. A synthetic modular approach is established to prepare-a)a prostate specific membrane antigen (PSMA) ligands for targeting the [...]