US – Page 173 – TechConnect Briefs

Plasmonic Nanobubbles as Tunable Theranostic Agents

Lukianova-Hleb E., Constantinou P., Danysh D.S. Wagner B., Drezek R.A., Hafner J.H., Farach-Carson M.C., Carson D.D., Farach-Carson M.C., Lapotko D.O., Rice University, US

Plasmonic nanobubbles (PNB) were developed to support a cell level theranostics as the multi-functional, tunable and selective cellular probes. PNB is a transient and tunable vapor nanobubble that is generated on demand around overheated plasmonic [...]

Label-free Raman Micro-Spectral Imaging of the Microenvironment of PANC-1 Spheroids

Chernenko T., Shah R., Zuser E., Diem M., Amiji M., Northeastern University, US

Spheroids are 3D tumor models, which reflect diverse properties of the growing tumor. Due to its avascular microenvironment, initial tumor growth patterns as well as subsequent tumor-core biochemistry may be studied in depth, from which [...]

New High Conductance DEP Devices for Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood

Heller M.J., Sonnenberg A., University of California San Diego, US

The ability to rapidly detect cell free circulating (cfc) DNA nanoparticulate biomarkers, drug delivery nanoparticles and virus directly from blood is a major challenge for nanomedicine. We have now developed unique, simple and practical high [...]

Nanoencapsulated Drug-Carrying System for Photodynamic Antimicrobial Chemotherapy (PACT)

Kalapala G.K.M., Fu P.K.-L., Governors State University, US

Chronic wounds are considered as a pandemic health problem. Approximately 1% to 2% of the population in developing countries has experienced a chronic wound during their lifetime. In the United State States,the expense of treating [...]

Concentration and characterization of influenza antigen bulks for potential novel vaccine delivery applications

Scampini A., Gallorini S., Baudner B.C., Palladino G., Singh M., O’Hagan D.T., Kommareddy S., Novartis, US

As a part of reformulating influenza vaccines by novel delivery technologies it is essential to work with concentrated antigens. The purpose of this study was to concentrate seasonal influenza monobulks, to characterize the concentrated antigens [...]

Encapsulation and in vitro characterization of protein in PLGA-chitosan nanoparticles for efficient protein delivery

Subbarayan P., Dennis V.A., Lee C., Nyairo E., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus (RSV) is one of the most common causes of severe respiratory tract infections affecting mainly elderly, infants and the immunocompromised worldwide. As yet, a safe and effective vaccine has not been developed [...]

Cationic Nanoparticles Effectively Delivered VEGF SiRNA in A549 Cells

Yang T., Li X., Liu Y., Liu Y., Bai S., Husson University, US

Recent discovery of small interfering RNA (SiRNA) that silences growth factors appears to improve effectiveness and safety of cancer therapy. Unfortunately, delivery of SiRNA to cancer cells is a major obstacle. Our work is focused [...]

Liposomes loaded with rifampicin and tobromycin for anti-Staphylococcus aureus action

DeSilva M.N., Zhao W.W., Schultz S.T., Whang K., Chu L., Naval Medical Research Unit San Antonio, US

Reducing patient recovery time and potential post surgical complications of warfighters after traumatic injury is of importance for the military. However, a current medical challenge in treating warfighters with traumatic injuries is bacterial infection due [...]

Spectrally-Selective Light-Induced Release from Gold-Coated Liposomes

Leung S.J., Romanowski M., University of Arizona, US

To address unmet medical needs in the area of controlled delivery, we recently presented liposome-supported plasmon resonant gold nanoshells. These composite structures are degradable into components of a size compatible with renal clearance, potentially enabling [...]

Plasmonic Nanobubbles for Intracellular Targeting and Gene Therapy

Lukianova-Hleb E., Wen J., Meteletsa L., Brenner M., Chang J., Lapotko D.O., Rice University, US

Intracellular molecular targeting (IMT) and gene transfection of eukaryotic cells is widely used for research and for developing gene cell therapy. However, the existing IMT methods lack selectivity, efficacy and safety when heterogeneous cell systems [...]