US – Page 114 – TechConnect Briefs

Isolation and Detection of Cancer Related DNA Nanoparticulate Biomarkers Directly from CLL Patient Blood “Rapid Sample to Sequence Diagnostics”

Heller M.J., Marciniak J., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA biomarkers continues to become more widely used for cancer diagnostics and management. Cfc-DNA ranges from nucleosomes and high molecular weight DNA nanoparticulates to 100-200bp fragments. We have [...]

Pharmacokinetics and Safety Studies of Low Molecular Weight Heparin Nanoconjugates

Yang T., Bouchard B., Cook A., Hu J., Hao J., Bai S., Husson University, US

Low molecular weight heparins (LMWHs) have received widespread acceptance as the first choice for initial prevention and treatment of venous thromboembolism via subcutaneous injection one to two times daily in the clinic. The need for [...]

Magnetic Targeting of Human Aortic Smooth Muscle Cells for Rapid Closure and Healing of Intracranial Aneurysm/Pseudoaneurysm

Arias S.L., Alucozai M., Pastrana F., Reece L.M., Kempaiaih R., Pavon J.J., Allain J.P., Purdue University, US

A novel approach is proposed in this study using a magnetic strategy to address the current disadvantages of detachable coils and stent grafts for aneurysm/pseudoaneurysm treatment. It consists of a patch facing the aneurysm neck [...]

Reversing Coagulopathy and Internal Hemorrhage with Functionalized Nanoparticles

Kudela D., May-Masnou A., Smith S.A., Braun G., Pallaoro A., Chuong T., Morrissey J.H., Stucky G.D., University of Californi, Santa Barbara, US

Uncontrolled hemorrhage is a major cause of preventable death. Wound treatment focuses on using nanostructured oxide and clay-based materials to quicken clot formation. Internal injuries further complicate treatment due to inaccessibility. In response to severe [...]

Poly-Vinyl Pyrrolidone (PVP)-coated Silver (Ag) Nanoparticles (Ag-PVP): a Potential to Regulate Chlamydia trachomatis Inflammation

Yilma A.N., Singh S.R., Dixit S., Hidat G.G., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is an important cause of sexually transmitted infection that can manifest itself as either acute cervicitis, pelvic inflammatory disease, and more commonly as a chronic asymptomatic infection. Previously we reported Ag-PVP (5-10 nm) [...]

Commercializing unique nanoparticle-imaging-delivery platform technology for enhanced cancer therapy

Fu A., NVIGEN, Inc., US

In this presentation, we will talk about a unique nanoparticle-imaging-delivery platform developed at NVIGEN, Inc. for enhanced cancer therapeutic applications. Our proprietary nanoparticle-imaging-delivery (NID™) technology is a hybrid platform comprised of an intrinsically signal-generating component [...]

Development of Drug Delivery System Using Bio based Calcium carbonate Nanoparticles

Render D., Rangari V., Samuel T., Ramapuram J., Pawar K., Jeelani S., Tuskegee University, US

The CaCO3 nanoparticles were derived from egg shells using sonochemical and mechanochemical methods. The glycerol and acetic acid were used as solvents in this process to avoid other toxic solvents. These nanoparticles were loaded with [...]

Programming and switching the pharmacokinetics of nanoscale delivery vehicles in vivo

Chien M.-P., Gianneschi N.C., University of California San Diego, US

It has been shown that the morphology of nanomaterials greatly impacts the pharmacokinetic profile of the material, with larger micronscale fibril-like objects having longer circulation times while smaller nanomaterials show a greater rate of internalization [...]

Nanosystem for targeting Treg in vivo

Bottini M., Bottini N., Sacchetti C., Rapini N., Rosato N., Magrini A., Bottini M., Bottini N., Sanford Burnham Medical Research Institute, US

Due to their ability to suppress the activity of autoreactive cells, “natural” CD4+ CD25high FoxP3+ T cells (Treg) are important drug targets for autoimmune diseases and malignancies. Immunological studies are revealing a growing subset of [...]

Thermosensitive Vaginal Gel Containing PLGA-NTRI Conjugate Nanoparticles for HIV Prophylaxis

Rajca A., Li Q., Date A., Destache C., Creighton University School of Pharmacy & Health Professions, US

A critical component to the prevention of the sexual transmission of HIV is adherence to the prevention modality. We have conjugated nucleoside-reverse transcriptase inhibitors (NRTIs) to a biocompatible polymer, PLGA using an amide bond. We [...]