SE – Page 2 – TechConnect Briefs

Timed release of cerebrolysin using titanate nanospheres induces neuroprotection in Parkinson’s Disease

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Ozkizilcik A., Tian Z.R., Patnaik R., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Military personnel during combat operations are highly susceptible to traumatic brain and spinal cord injury. There are reasons to believe that a focal injury to the central nervous system (CNS) causes multiple biochemical and pathological [...]

Nanodelivery of drugs for therapeutic strategies in CNS disorders. Current and Future perspectives

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Nanodelivery of drugs, diagnostic agents and other functionalized nanoparticles aiming for better treatment of diseases or diagnosis purposes are the new trends in medicine that appear promising. However, nanoparticles or nanotechnology used to deliver these [...]

Nanodelivery of Cerebrolsyin in combination with neprilysin induces neuroprotection in Alzheimer’s Disease pathology following brain injury

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Neprilysin (NPL) is an endogenous enzyme that functions as rate-limiting step in amyloid-beta peptide (AβP) degradation. There are reasons to believe that an imbalance between production and clearance of AβP results in its accumulation leading [...]

Novel encapsulation technology based on Pickering emulsion systems

Sjöö M., Bedi J., Ali A., Speximo AB, SE

A novel technology based on using particles of biological origin for stabilizing emulsions, so called Pickering emulsions, was recently developed. This technology was further employed to encapsulate different types of active substances. Advance development and [...]

Solid State and Diffusion NMR Spectroscopy as Applied to Characterization of Complex Formulated Products and Biological Materials

Ulvenlund S., Topgaard D., Gustavsson S., Sparr E., CR Competence AB, SE

Solid and semisolid formulations in pharmaceutics, cosmetics and foods normally comprise complex structures on the molecular and colloidal length scales. Proper understanding of the functionality of a formulated product, as well as rational optimization of [...]

Helping nano-entities discover their nano-identity

Castro A., Leeman M., Runyon J.R., Nilsson L., Ulmius Storm M., SOLVE Research and Consultancy AB, SE

Nanoscale materials are becoming increasingly prevalent in our lives. The strategies required to characterize the properties and performance of nanoscale materials can be as unique as the material itself. We have experienced that separation of [...]

TiO2 Nanowired Cerebrolysin enhances neuroprotective effects of mesenchymal stem cells following concussive head injury at hot environments

Sharma A., Sharma H.S., Muresanu D.F., Feng L., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Concussive head injury (CHI) could lead to either instant death or lifetime disabilities. Our soldiers are highly vulnerable to CHI during combat operations. Thus, to treat these soldiers effectively novel strategies using combination therapy is [...]

Mn nanoparticles exacerbates closed head injury induced blood-brain barrier disruption, brain pathology, and sensory motor dysfunctions. Neuroproetction by Nanowired delivery of 5-HT2 receptor antagonists Ketanserin and Ritanserin

Sharma A., Sharma H.S., Feng L., Muresanu D.F., Lafuente J.V., Tian Z.R., Ozkizilcik A., Smith M.A., Sharma A., Sharma H.S., Uppsala University, SE

This innovation deals with adverse effects of Mn nanoparticles on brain pathology in concussive head injury. Also Mn nanoparticles treatment alters therapeutic modalities. The novel data presented in the abstract show that Mn exposure to [...]

Nanodelivery of Cerebrolysin Induces Profound Neuroprotection in Heat Stroke Following Chronic Hypertension in Combination with SiO2 and Carbon Nanoparticles Induced Exacerbation of Brain Damage

Muresanu D.F., Sharma A., Sharma H.S., Patnaik R., Nozari A., Mössler H., Tian Z.R., Ozkizilcik A., Sharma A., Sharma H.S., Uppsala University, SE

Our military personals are often exposed to combat stress induced hypertension in an environment rich in various nanoparticles emanating from different sources e.g., gun powder explosion or blast injuries. Furthermore, combat or peacekeeping activity in [...]

Nanomedicine in Neurodegenerative Disorders: understanding the journey

Tosi G., Ruozi B., Vilella A., Grabrucker A.M., Belletti D., Vandelli M.A., Boeckers T.M., Forni F., Zoli M., Sharma A., Sharma H.S., Muresanu D.F., Sharma A., Sharma H.S., Uppsala University, SE

The novelty of the last 3 years of research is on the fate of NPs made of poly-lactic-co-glycolic acid (PLGA) and engineered with g7, a glycopeptide that enhances BBB crossing capability, in the living mouse [...]