DK – TechConnect Briefs

Novel fluorescent nanoparticles for ultrasensitive identification of nucleic acids by optical methods

Westergaard Mulberg M., Taskova M., Okholm A., Kjems J., Astakhova K., University of Southern Denmark, DK

There have been an enormous interest in new amplification-free detection methods. A tremendous progress has been made in fluorescence based optical detection of biomolecules, which here resulted in the synthesis of novel ultra bright fluorescent [...]

Amplification-free liquid biopsy by fluorescence approach

Uhd J., Taskova M., Okholm A., Astakhova K., University of Southern Denmark, DK

Diagnostics of cancer associated ctDNA, BRAF V600E, KRAS G12D and KRAS G13D respectively. By the use of modern fluorescence microscopy and fluorescently labeled mutation specific LNA/DNA probes. Which resulted in a mutation specific detection.

Plasmonic Nanopillar Structures for Surface-Enhanced Raman Scattering Applications

Rindzevicius T., Schmidt M.S., Wu K., Thilsted A.H., Lauridsen R.K., Alstrøm T.S., Palla M., Yang J., Boisen A., Technical University of Denmark, DK

Nanosized noble metal structures support localized surface plasmon (LSPR) resonances that depend on their dimensions, shapes and compositions. Particle LSPR’s can be used to spatially confine the incident light and produce enormous electromagnetic field enhancement [...]

Plasmonic Structural Colors For Plastic Consumer Products

Højlund-Nielsen E., Clausen J., Thamdrup L.H., Zalkovskij M., Højlund-Nielsen E., Nielsen T., Mäkelä T., Ahopelto J., Mortensen N.A., Kristensen A., Technical University of Denmark, DK

Today colorants, such as pigments or dyes, are used to color plastic-based consumer products, either as base for solid colored bulk polymer or in inks for surface decoration. After usage, the products must be mechanically [...]

Plasmon enhanced silver quantum cluster fluorescence for biochemical applications

Bernard S., Kutter J.P., Mogensen K.B., Technical University of Denmark, DK

Silver quantum clusters (AgQCs) consisting of typically 4-10 atoms and known to be highly fluorescing in the visible wavelength range. Here, plasmon-enhanced silver quantum cluster fluorescence is employed for chemical sensing in a simple microfluidic [...]

Blueshift of the silver plasmon band using controlled nanoparticle dissolution in aqueous solution

Mogensen K.B., Kneipp K., Technical University of Denmark, DK

In this work, we report the size-dependent blue shift of the silver nanoparticle (AgNP with radius R) plasmon band in aqueous solution by means of UV/VIS spectroscopy. An oxidative dissolution scheme using cyanide in the [...]

Synthetic LNA/DNA Nano-scaffolds for Highly Efficient Diagnostics of Nucleic Acids and Autoimmune Antibodies

Astakhova I.K., University of Southern Denmark, DK

Herein we describe fluorescent oligonucleotides prepared by click chemistry between novel alkyne-modified locked nucleic acid (LNA) strands and a series of fluorescent azides for highly efficient homogeneous (all-in-solution) detection of nucleic acids and autoimmune antibodies. [...]

Country: DK