Somatostatin peptides such as somatostatin 28 or 14 are known for their high binding affinity to G-coupled peptide receptors, which are often over-expressed on tumor cells. Using this binding property we developed a new type [...]
The problem of initial burst release, in sustained drug delivery devices was resolved by reducing the active pharmaceutical ingredient particle size by using Supercritical Antisolvent technique with Enhanced Mass-transfer (SAS-EM)., Encapsulation was performed using a [...]
Zheng et al. (2004) developed a multiscale, twodimensional tumor simulator with the capability of showing tumoral lesion progression through the stages of diffusion-limited dormancy, neo-vascularization (angiogenesis) and consequent rapid growth and tissue invasion. In this [...]
Novel nanoparticulate drug delivery systems have received increasing attention for delivery of poorly water-soluble drugs and proteins. We have developed a new type of polymer micelles bearing the hydrotropic core segment, e.g., poly(2-(4-vinylbenzyloxy)-N,N-diethylnicotinamide), that enables [...]
Our main goal is to develop micro/nano-scale self-assembling delivery vehicles for cutaneous gene therapy. The objective of this study was to characterize the structural and physicochemical properties of novel dicationic lipid-based DNA complexes by atomic [...]
, Costello M.
, Dormer K.
, Gibson D.
, Jackson R.
, Kopke R.
, Liu J.
, Mamedova N.
, Mondalek F.
, NanoBioMagnetics, Inc, US
An obstacle to effective treatment of inner ear diseases is the atraumatic delivery of therapeutics into inner ear perilymph. This study reports on the feasibility of using superparamagnetic nanoparticles as drug delivery vehicles.
Artificial cells (AC) refer to (sub) micro-vehicles that can perform a specific bio-function in the body, without being rejected from the immune system. Such smart targeting and drug delivery systems are aimed for use in [...]
The nano-structured vaccine delivery systems, containing tomatine, n-octyl-b-D-glucopyranoside (OGP), phosphatidylethanolamine (PE), cholesterol, and ovalbumin, were examined in the present study by transmission electron microscopy. This adjuvant has been shown to elicit cytoxic T-lymphocyte (CTL) effect [...]
Bioferrofluid obtained using iron coated nanoparticles are promising candidates for magnetic drug delivery. The carbon cages made the particles biocompatibles and provide a suport for drug adsortion. We propose a new method in which gold [...]
Degradable polymeric materials that can be storage for months in aqueous enviroment before undergoing on-command controlled swelling and degradation were prepared and their kinetics of swelling and degradation were evaluated. The swelling and degradation rates [...]
Superparamagneticiron oxide nanoparticles (SPION) were mixed at various ratios with different polymer solutions to obtain SPION coated with PVA modified by functional groups (amino-SPION, carboxy-SPION, and thiol-SPION). Studying human melanoma cells by theses different functionalized [...]
We herein report the overall goals of the joint project “Nano-Health” and preliminary results of two sub-projects (Nano-Health started in October 2004), which was positive evaluated by international reviewers within the first Call of the [...]
Conventional oral dosage forms deliver their active ingredient at rates that are high initially and decline afterward, showing a first order kinetics with the release determining step considered as the dissolution rate of the active [...]
A number of novel delivery systems have been developed including the entrapment of drugs, proteins, antigens, or genes in small vesicles or within polymeric matrices. Colloidal delivery systems such as liposomes, microemulsions, and polymeric micelles [...]
Enhancement of DNA delivery efficiency has been improved by several physical and chemical approaches in the past decade. However, the application of those methods is hampered by large-scaled configurations. To augment gene delivery efficiency with [...]
Protein nanoparticles can be utilized for the pulmonary delivery of protein therapeutics or can be incorporated into biodegradable polymer microspheres/nanospheres for controlled release depot or oral delivery. With proteinaceous therapeutics, the generation of nanoparticles is [...]
A new method was presented for controllable preparation of 10-nm-scale drug carriers based on the phase behaviors of hot microemulsions. This method is suitable for preparation of nanodrug of many water insoluble drugs.
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: May 8, 2005
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery