Papers – Page 62 – TechConnect Briefs

Specific device for cells sampling

Cosnier M.L., Martin F., Ratel D., Berger F., Caillat P., Commissariat à l’Energie Atomique, FR

We developed a miniaturized biopsy tool for harvesting molecules of interest in delicate areas such as brain. This tool permits harvesting of intact cells permitting genomic analysis on these cells. The sampling tool is manufactured [...]

Biochip-Based Test System for Cancer Diagnostics. Simultaneous Quantitation of Total and Free Forms of Prostate-Specific Antigen

Osipova T., Sokolova Z., Ryabykh T., Karaseva V., Modorsky M., Matveev V., Baryshnikov A., N.N. Blokhin Cancer Research Center, RAMS, RU

Background. Prostate-specific antigen (PSA) is the most useful marker for the early detection of prostate cancer (PCa). The use of two PSA forms – total (PSAt) and free (PSAf) makes it possible to differentiate benign [...]

Chitosan Nanoparticle Combined with Ultrasound for Cervical Cancer Detection

Tsai K-C, Shieh M.J., Yang S.J., Lin W-L, Chen W-S, Institute of Biomedical Engineering, TW

Photodynamic medicine is a novel approach for cancer detection and treatment via different photosensitizers and suitable light source. The 5-Aminolevulinic acid (5-ALA) can be converted into protoporphyrin IX (PpIX) that can be utilized as a [...]

Colorectal Cancer Cell Detection by Chitosan Nanoparticle Conjugated with Folic Acid

Yang S.J., Chen J-W, Shieh M.J., Institute of Biomedical Engineering, TW

Endoscopy is a common diagnosis device for the detection of colorectal cancer and there are two methods to improve the diagnostic sensitivity. One is chromoendoscopy, and the other is magnifying endoscopy. Color contrast dye, such [...]

Genomics and Proteomics: Information-Theoretic Analysis in Frequency Domain

Lyshevski S.E., Krueger F., Rochester Institute of Technology, US

We perform the frequency-domain analysis to examine large-scale genomic and proteomics data. This ensures qualitative and quantitative coherency.

Multiwalled Carbon Nanotube-Doxorubicin Supramolecular Complexes for Cancer Therapeutics

Ali-Boucetta H., Al-Jamal K.T., Kostarelos K., The School of Pharmacy, University of London, UK

The field of drug delivery is being revolutionised by the discovery of novel nanomaterials such as carbon nanotubes (CNTs) capable of traversing the plasma membrane and promoting the cellular uptake of small molecules and macromolecules [...]

5-aminolevulinic Acid Conjugated Gold Nanoparticles for Cancer Treatment

Khaing Oo M.K., Yang X., Wang H., Du H., Stevens Institute of Technology, US

To improve 5- aminolevulinic acid’s (5-ALA) selective retention in tumor cells and efficient damage tumor cells in photodynamic therapy (PDT), biocompatible gold (Au) nanoparticles were proposed as the carrier to selectively deliver 5-ALA into tumor-like [...]

Strategies for enhanced brain tumor accumulation of magnetic nanoparticles for potential drug delivery

Chertok B., David A.E., Yang V.C., University of Michigan, US

The purpose of this study was to elucidate strategies to enhance magnetically mediated accumulation of iron-oxide-based nanoparticles in brain tumors for potential localized delivery of chemotherapeutic agents. In particular, we evaluated administration of the nanoparticles [...]

Gold Nano-Probes as Targeted CT Contrast Agents for In-vivo cancer Imaging

Popovtzer A., Popovtzer R., Agrawal A., Shlomi M., Popovtzer A., Popovtzer R., Balter J., Carey T.E., Kopelman R., University of Michigan, US

This research describes a new class of immuno-targeted and cancer specific CT contrast agents, which enable CT imaging of cancer at cellular and molecular resolution. The method is based on the development of gold nano-probes [...]

Nanomedicine: Engineering of a Tri-Imageable Nanoparticle for Cancer Diagnostics

Bumb A., Dobson PJ., Fugger L., Choyke P., Brechbiel MW., National Cancer Institute/University of Oxford, US

We have created a potential targeted drug delivery platform with three imaging reporters by coupling the magnetic properties of USPIOs with near infrared fluorescence of Cy5.5 and gamma emissions of Indium-111 that is chelated to [...]