Papers – Page 48 – TechConnect Briefs

In Vitro Toxicity Study of Gold and Tin Composite Nanodevices for use in Imaging and Radiotherapy

Khan M.K., Kariapper M.S.T., Kasturirangan V., Nair B., Lesniak W., Balogh L.P., Roswell Park Cancer Institute, US

Composite nanodevices, with PAMAM dendrimer and inorganic metal components, are currently being developed as an exciting nanoplatform for several types of molecularly targeted cancer therapy and imaging. Due to its unique chemical structure of dendrimers, [...]

Inflammation and Cellular Toxicity Study of PAMAM Dendrimer Nanoparticles in Primary Isolated Human Lung Cells

Khan M.K., Kariapper M.S.T., Kasturirangan V., Lesniak W., Sharma M., Baumann H., Balogh L.P., Translational Research Scientist, US

Poly(amidoamine) (PAMAM) based dendrimers are a class of organic particulate nanomaterials with great promise for improvement in cancer imaging and therapy. In this study, we systematically modify terminal groups of the parent generation 5 primary [...]

Use of Nanoparticles as Therapy for Respiratory Syncytial Virus Inhibition

Vig K., Boyoglu S., Rangari V., Sun L., Singh A., Singh S.R., Pillai S., Singh A., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus is the leading cause of severe respiratory illnesses such as bronchiolitis and pneumonia in young children. RSV is a paramyxovirus with negative-sense genomic RNA that encodes for eleven proteins, two of which, [...]

Emerging Trends of Nanotechnology towards Picotechnology: Energy and molecules

Sharma A., Sharma R., Sharma A., Sharma R., Chen C-J., Florida State University, US

In nature, metal oxide particles display their existance at the level of picomolecules in solution state and bioactive states in the body. We put evidence of picomolar behavior of molecules different than nanomolar behavior of [...]

Upconverting nanoparticles for in vitro and in vivo cellular imaging

Chatterjee D.K., Zhang Y., National University of Singapore, SG

Conventional fluorescent labels are of limited in vivo utility because short-wavelength radiation penetrates tissues poorly and excites strong background autofluorescence. Upconversion nanoparticles (UCN) convert low-energy exciting photons to visible emissions, resulting in deep tissue penetration [...]

The therapeutic effects of silver nanoparticle on the inflammatory disease of the temporomandibular joint

Kim A.S., Kim S-G, Kim A.S., Kim S-G, Lee A.R., Hallym Univerisity, KR

Purpose: The objective of this study was to exam the therapeutic effects of silver nanoparticle on the inflammatory disease of the temporomandibular joint in the animal model. Materials and Method: Mustard oil was injected to [...]

Non-Condensing Calcium Alginate Microspheres for Macrophage-Selective Gene Delivery and Transfection

Jain S., Amiji M., Northeastern University, US

The main objective of the study was to design a non-condensing polymer microsphere-based gene delivery system for macrophages. An external gelation technique was used to prepare plasmid DNA-encapsulated calcium alginate microspheres. The microspheres were characterized [...]

Removing Active Species by Fullerenol in vitro and in vivo

Yin J-J., Lao F., Wamer W-G., Zhao Y., Gao X., Wang P-C, Chen C., Liang X-J., National Center for Nanoscience and Technology of China, CN

We previously demonstrated that gadolinium endohedral metallofullerenol ([Gd@C82(OH)22]n nanoparticles) had high inhibitory activity on growth of malignant tumor in vivo by uncertain mechanism(s). The activities of enzymes associated with the metabolism of reactive oxygen species [...]

Novel Resorbable Drug-Carrying Nano-Scaffolds for Treating Bone Diseases at Targeted Sites

Liu H., Webster T.J., Brown University, US

Pharmaceutical agents are often required to stimulate new bone formation for the treatment of bone injuries or diseases (such as osteoporosis and osteosarcoma). However, there are several problems associated with current drug delivery methods. First, [...]

Carbon Nanopipes dispersions in aqueous solutions and effects on cell viability

Whitby M., Lin J., Quirke N., Thanou M., Imperial College London, UK

The development of carbon nanomaterials for biomedical applications appears highly attractive due to their nanoscale properties although their biological profile is still in doubt. Herewith, we report that the amorphous vs crystalline character of carbon [...]