Materials Characterization & Imaging – Page 43

Synthesis of Dextran-Coated Nanoceria with pH-dependent Antioxidant Properties

Perez J.M., Asati A., Nath S., Kaittanis C., University of Central Florida, US

Cerium oxide nanoparticles (nanoceria) are potent free radical scavengers with neuroprotective, radioprotective, and anti-inflammatory properties. However, most synthetic procedures for nanoceria results in nanoparticles with poor water solubility or synthesized by procedures involving toxic solvents, [...]

Effect of functionalization on the self-assembling propensity of beta sheet forming peptides

Taraballi F., Campione M., Vescovi A.L., Sassella A., Hwang W., Paleari A., Gelain F., University of Milan-Bicocca, IT

Synthetic polymers and bioinspired fibrous materials have a significant impact in medicine in the recent years. The design and fabrication of new bio-materials has a great influence in several scientific and medical communities. The potential [...]

Enhancement of in vitro Capillary Tube Formation by Substrate Nanotopography

Bettinger C.J., Zhang Z., Gerecht S., Borenstein J.T., Langer R., Massachusetts Institute of Technology, US

Controlling the morphology and function of cells using substrate nanotopography is a phenomenon that can be utilized in a variety of fields including tissue engineering and regenerative medicine. In this work, we explored the possibility [...]

Exploring the behavior of concentrated collagen, approaches to tailor biomimetic materials

Gobeaux F., Mosser G., Anglo A., Panine P., Davidson P., Giraud-Guille M.-M., Belamie E., Ecole Pratique des Hautes Etudes, FR

Dense ordered collagen matrices can be obtained by fine tuning the electrostatic interactions in highly concentrated solutions of type I collagen. Such biomimetic fibrillar materials have a high application potential in the field of tissue [...]

Investigating Helical Rosette Nanotubes and Nanocrystalline Hydroxyapatite as Novel Bone-like Biomaterials for Orthopedic Applications

Zhang L.J., Rodriguez J., Fenniri H., Webster T.J., Brown University, US

The objective of this study was to create a novel biomimetic hydrogel composite based on helical rosette nanotubes (HRNs) and nanocrystalline hydroxyapatite (HA). HRNs are newly-developed self-assembled nanomaterials with DNA base pair building blocks. HRNs [...]

Multifunctional nanoparticle platforms for pathogen diagnostic applications

Kell A.J., Paquet C., Simard B., National Research Council, CA

Infectious diseases and bioterrorism are of tremendous global concern, and our group is interested in developing superparamagnetic nanoparticle platforms that can aid in the magnetic extraction/concentration and detection of harmful pathogens. This has led to [...]

Biomolecular activity switch: an application of metallic nanoparticle plasmon resonance

Alper J., Wijaya A., Crespo M., DeFlores L., Tokmakoff A., Hamad-Schifferli K., Massachusetts Institute of Technology, US

Specific external control of biomolecular activity is a critical step in harnessing the power of nature’s molecular machinery. We propose and demonstrate one control method, a biomolecular activity switch. Since proteins are the primary macromolecule [...]

2-Nitroimidazole as Potential Nanoprobe in Hypoxia Imaging by MRI/PET

Sharma A., Sharma R., Sharma A., Sharma R., University of North Carolina, US

2-Nitroimidazole is radiosensitizer and serves as imaging contrast agent by 19F- and 31P MR methods. Despite the success of mesonidazole and SR-4554 compounds, very little is known of its hepato-cytotoxicity if it can be potential [...]

Multiplexed Proteolytic Enzyme Assay Based on Energy Transfer between Quantum Dots and Gold Nanoparticles

Oh Y.H., Kim H-S, Kim Y.P., Kim H-S, Kim Y.P., Korea Abvanced Institute of science and Technology, KR

Proteases are key enzymes that regulate both normal and malignant tumor progress. Evaluating these enzymes and their inhibitors, therefore, has a great potential to diagnostics or therapeutic treatment against specific diseases or disorders. We have [...]

Towards nanosized particles in pharmaceutical industry

Bieri N.R., Meier U., Goncalves E., Zimmermann D., Juhnke M., Thakur R., Novartis Pharma AG, CH

The pharmaceutical industry is facing the problem of an increasing number of drug substances in development which are either poorly water soluble or show pH dependency of solubility. Drug targeting and tailored delivery poses additional [...]