Environmental Health & Safety of Nanomaterials – Page 23

Fate, Transport, and Toxicity of Nanomaterials in Drinking Water

Zhang Y., Koeneman B.A., Chen Y., Westerhoff P., Capco D.G., Crittenden J., Arizona State University, US

The objective of this research is to evaluate the potential risk of human exposure to nanomaterials in drinking water by examining three issues: 1) characteristics and stability of nanomaterials in the water environment; 2) removal [...]

Cell-based Assays for Cytotoxic and Pro-inflammatory Effects of Gold Nanoparticles

Knight T., Wise S.S., Wise_Sr. J.P., Mason M.D., Wise_Sr. J.P., Ng A-K., University of Southern Maine, US

This study aims at developing cell-based assays to assess the potential cytotoxic and proinflammatory effects of nanomaterials, using 15 nm gold nanoparticles as a model. In a MTT cytotoxicity assay, significant cytotoxicity was found in [...]

Differential Cytotoxicity of Metal Oxide Nanoparticles

Chen J., Zhu J., Cho H.-H., Cui K., Li F., Zhou X., Rogers J.T., Wong S.T.C., Huang X., Brigham and Women's Hospital, Harvard Medical School, US

There are growing concerns among the general public and regulators about their potential health hazard. To determine the potentially toxic responses of CNS due to exposure of metal oxide nanoparticles, human SH-SY5Y neuroblastoma and H4 [...]

Biodistribution and Toxicity of Nanomaterials In Vivo: Effects of Composition, Size, Surface Functionalization and Route of Exposure

Harper S.L., Maddux B., Hutchison J., Tanguay R.L., Oregon State University, US

Given the anticipated growth of the nanotechnology industry and the deficiency of toxicological information, there is an obvious need for rapid, relevant and efficient testing strategies to evaluate the biological activity and toxic potential of [...]

An integrated NMR/nanosensor system for sensitive detection of environmental toxins and harmful microbes

Perez J.M., Fries D.P., Hickman J.J., University of Central Florida, US

The use of nanoparticles and NMR detection technologies has lead to significant improvements in sensitivity. Nanoparticles have many useful optical and electronic properties derived from their small size. When coupled to affinity ligands, these materials [...]

Stable Isotope Tracing – a way forward for Nanotechnology?

Gulson B., Wong H., McCall M., Danon S., Greenoak G., Trotter J., Casey P., Stauber J., Commonwealth Scientifc and Industrial Research Organisation, AU

Numerous publications and reports have expressed health and safety concerns about the production and use of nanoparticles, especially in areas of exposure monitoring, personal use, and environmental fate and transport. We suggest that stable isotopic [...]

Toxicogenomics study of nanomaterials on the model organism zebrafish

Rojo I., Uriarte M., Obieta I., Bustero I., Egizabal A., Pardo M.A., Martínez de Ilárduya O., Azti-Tecnalia, ES

The applications of nanomaterials include fields as biomedicine, cosmetics or food science, raising a concern about the need to determine their toxic effects. Most of the toxicity tests are based on the analysis of classical [...]

An OMICs Approach for Assessing the Safety of Single-Walled Carbon Nanotubes in Human Skin and Lung Cells

Cunningham M.J., Shah M., Lema C., Magnuson S., Falduto M., Balzano L., Resasco D., Houston Advanced Research Center, US

High-throughput OMICs biotechnologies combined with a systems biology approach were used to screen for the toxicity of nanomaterials. Profiling of the macromolecular interactions within human cells was done with mRNA and miRNA expression microarrays (genomics) [...]

Cytotoxicity of Dental Nanocomposite Particles

Kostoryz E.L., Utter C.J., Wang Y., Dusevich V., Spencer P., University of Missouri-Kansas City, US

Safety assessment of dental composites is focused on the toxicity of leachable unreacted monomers. With the advent of nanostructured materials, safety assessment needs to include the potential toxicity of nanoparticles. The objective of this study [...]

Nanotechnologies and Health Maintenance

Rae A., NanoDynamics, US

We have all heard about the marvelous advances being made in the use of nanomaterials in imaging, cancer therapy and controlled release pharmaceuticals. What is less well known is the role of nanotechnology in prevention [...]