Diagnostics & Bioimaging – Page 19

Gold Nanoparticles as contrast media in dual-energy radiography: a monte carlo study

Jackson P.A., Geso M., RMIT University (Royal Melbourne Institute of Technology), AU

There has been recent interest in the use of gold nanoparticles as contrast media in cancer diagnosis. This utilises either a high-concentration suspension to highlight all areas of vasculature or as an antibody-conjugated species with [...]

Gold nanoparticles and emerging applications in imaging

Sharma A., Sharma R., Sharma A., Sharma R., Florida State University, US

Au from Au–Ag core–shell nanoparticles acts as multimodal Gold-speckled silica nanoparticles as contrast agents for noninvasive imaging with magnetic resonance imaging and photoacoustic tomography. These Au nanopeanuts can be prepared in a simple one-pot synthesis [...]

Copper 64-Cu nanoparticles in multimodal imaging of carotid artery disease

Sharma A., Sharma R., Sharma A., Sharma R., Florida State University, US

Nanoparticle based hybrid imaging by MRI, PET-CT and Fluorescent reflectance techniques are emerging in imaging carotid artery disease. 64Cu-TNP is detectable by MRI and PET-CT. A trimodality reporter 64Cu-TNP is a derivatization product made of: [...]

Analysis of an Optofluidic Biochemical Sensor

Furlani E.P., Biswas R., Litchinitser N.M., University at Buffalo, US

In this presentation we introduce a novel optofuidic biochemical sensor in which detection is based on the contrast between the refractive index of a target biomaterial and the ambient carrier fluid. The sensor consists of [...]

AuAg-alloy-nanoprobes for specific nucleic acid detection

Doria G., Larguinho M., Dias J.T., Pereira E., Franco R., Baptista P., CIGMH/DCV & REQUIMTE/DQ, PT

Due to their unique optical properties, noble metal nanoparticles, and in particular gold nanoparticles (AuNPs), have been extensively used for the development of new molecular diagnostic assays[1]. These optical properties derive from the characteristic surface [...]

A comparative study on sensitivity for biomolecular detection between gold nanoparticles coated and uncoated gold thin film using spectroscopic ellipsometry

Moirangthem R.S., Chang Y-C, Hsu S.-H., Wei P.-K., Research Center for Applied Sciences, TW

We investigate the plasmonic responses of gold nanoparticles (AuNP) coated and uncoated on 30nm gold thin film with aqueous medium having different refractive index using SPR ellipsometry. (See Figure 1) The sensitivities in both cases [...]

Integrated lab-on-a-chip Influenza diagnostic designed for low cost manufacturing

Sauer-Budge A.F., Mirer P.L., Chatterjee A., Klapperich C.M., Sharon A., Fraunhofer USA, US

In this paper we describe a completely integrated lab- on-a-chip for genetic analysis of bacteria or viruses. The chip was designed for low cost manufacturing in thermoplastics by choice of low cost materials (thermoplastics) and [...]

Multiplexed protein detection using antibody-conjugated microbead arrays assembled on a microfabricated electrophoretic device

Barbee K.D., Hsiao A.P., Roller E.E., Huang X., UCSD, US

We report the development of a microfabricated electrophoretic device for assembling high-density arrays of antibody-conjugated microbeads for chip-based protein detection. The device consists of a flow cell formed between a gold-coated silicon chip with an [...]

DNA Extraction, Purification and Quantification Using Micromachined Microfluidic Chip

Azimi S.M., Nixon G., Ahern J., Balachandran W., Brunel University, UK

This paper introduces a new DNA extraction and purification method from whole blood. Mixing and separation steps are performed using functionalised superparamagnetic beads suspended in cell lysis buffer in a circular chamber that is sandwiched [...]

Microfluidic Devices for Rapid Separation and Sensing of Cells

Bose S., Lee C.H., Karp J.M., Karnik R., Massachusetts Institute of Technology, US

We report a new method to separate cells in microfluidic devices by directing the trajectories of cells along asymmetric receptor edges. This approach relies on cell rolling, a physiological phenomenon involving transient interactions of the [...]