Diagnostics & Bioimaging – Page 16

Bio-inspired Optoelectronic Digital Nose

Bayindir M., Yildirim A., Vural M., Yaman M., Bilkent University, TR

We introduce and demonstrate the capabilities of a novel integrated optoelectronic-microfluidic sensor array that can rapidly distinguish millions of, trace level volatile chemicals based on their spectroscopic fingerprints inside flexible optofluidic channels. The system consists [...]

Highly robust array of nanosensing platform for biosensing application

Stateikina I., Ng A., Chinnappan R., Ahmed M., Zourob M., INRS, CA

This work presents a simple method of combining macro connectors with pre-fabricated nanovire chips. This design offers a unique ease and rapidity of connecting the nanowires with the connectors without using imaging and external aid [...]

From Rational Design to Probe Optimization: the Role of Nanoparticle Valency in Single Cancer Cell Detection in Blood via Magnetic Relaxation

Kaittanis C., Santra S., Perez J.M., University of Central Florida, US

The conjugation of targeting ligands to iron oxide nanoparticles has achieved the development of specific assays for the detection of biomedical targets through magnetic relaxation. However, limited studies investigated how the nanoparticle valency modulates the [...]

Identification of Molecular-Mimicry-Based Ligands for Cholera Diagnostics using Magnetic Relaxation

Santiesteban O.J., Kaittanis C., Banerjee T., Santra S., Teter K., Perez J.M., University of Central Florida, US

Magnetic nanosensors (MRnS) offer multiple benefits that can be used to design sensitive and robust diagnostic tools. High sensitivity, stability, and ease of surface modification make this approach a strong contender against the more commonly [...]

Portable gas sensor for breath analysis

Righettoni M., Tricoli A., Gass S., Pratsinis S.E., ETH Zürich, CH

The detection of acetone in the human breath is a promising method for the noninvasive diagnosis and monitoring of diabetes. Here, a portable and highly selective acetone-sensor was developed by direct flame synthesis and deposition [...]

A double-bead sandwich assay for protein detection in serum based on localized surface plasmon resonance

Jans H., Jans K., Jans H., Jans K., Stakenborg T., Borghs G., Maes G., Lagae L., IMEC, BE

In this study, the importance of pre-concentration is clearly demonstrated for the covalent immobilization of various proteins to magnetic nanoparticles through mild carbodiimide activation. Additionally, the covalently biofunctionalized magnetic nanoparticles are employed in a double-bead [...]

Topical Sensory Nanoparticles for in vivo Biomarker Detection

Patrone J., Benkoski J., Patchan M., Calderon-Colon X., Le H., Sample J., JHU/APL, US

We have recently developed a non-toxic, topically applied biosensor using solid lipid nanoparticles (SLN). This diagnostic platform is currently designed to continuously monitor hydrogen peroxide levels in skin. Overproduction of hydrogen peroxide is implicated in [...]

Bio Sensors, Diagnostics, Imaging & Instrumentation

Low-power / High-temperature sensors and MEMS in SOI technology

Moreno-Hagelsieb L., Bulteel O., André N., Gerard P., Raskin J-P, Flandre D., Université catholique de Louvain / SENSOI, BE

Low-power and high-temperature sensors and MEMS designs based on bulk, SOI and IC compatible materials and processes. Target markets are in general public sensors for UV, ozone, CO, liquids presence, e.g. in mobile devices. In [...]

Mathematical modeling and computer simulation of Brownian motion and hybridization of nanoparticle-bioprobe-polymer complexes in the low concentration limit

Toth A., Banky D., Grolmusz V., Eotvos University, HU

We present a mathematical model and the computer simulation of Brownian motion of nanoparticle-bioprobe-polymer contrast agent complexes and their hybridization to immobilized targets. Our model is a stochastic counterpart of the continuous model presented in [...]