Cancer Nanotechnology

Analysis of Magnetic Particle Capture in the Microvasculature

Furlani E.P., Ng K.C., Sahoo Y., University at Buffalo, US

An analytical model is described for predicting the capture of therapeutic magnetic nanoparticles in the microvasculature. The particles consist of a magnetic core coated with surface-bound anticancer agents, and are directed to a tumor using [...]

Development of Tumor Targeting Magnetic Nanoparticles for Cancer Therapy

Ivkov R., DeNardo G.L., DeNardo S.J., Miers L.A., Natarajan A., Foreman A.R., Gruettner C., Adamson G.N., DeNardo G.L., DeNardo S.J., Triton BioSystems, Inc., US

111In-ChL6 MAb-linked iron oxide nanoparticles (bioprobes) pharmacokinetics, tumor uptake and the therapeutic effect of inductively heating these bioprobes by an externally applied AMF were studied in athymic mice bearing human breast cancer HBT3477 xenografts. Bioprobe [...]

Development of peptide conjugated Superparamagnetic Iron Oxide (SPIO) Nanoparticles for Targeted MR Imaging and Therapy of Pancreatic Cancer

Yang L., Mao H., Cao Z., Wang A., Wang X., Peng X., Wang A., Wang X., Karna P., Adams G., Yuan Q., Staley C., Wood W.C., Nie S., Gao X., Emory University, US

We have engineered superparamagnetic iron oxide (IO) nanoparticles targeted to urokinase plasminogen receptors (uPAR), which is highly expressed in tumor cells, intratumoral fibroblasts and tumor endothelial cells and can also be internalized by cells. IO [...]

Modulation of Intracellular Ceramide using Polymeric Nanoparticles to Overcome Multidrug Resistance in Tumor Cells

van Vlerken L.E., Shenoy D., Duan Z., Seiden M., Mehta S., Amiji M.M., Northeastern University, US

This work describes the formulation of a nanoparticle drug delivery system to co-administer a chemotherapeutic, paclitaxel, and an MDR modulator, C6-ceramide, aimed at overcoming multidrug resistance (MDR) of solid tumors. MDR can arise through several [...]

Role of immunoregulators as possibility of tumor hypoxia-induced apoptosis

Sharma R., Kwon S., Chen C-J., Columbia University, US

IL-1, TNF-α and INF-γ cytokines stimulate in nitric oxide production and result with inflammation manifested by apoptosis and hypoxia. We propose that extent of inflammation leading to hypoxia initially and programmed cell death later both [...]

Temperature-Triggered Nanotechnology for Chemotherapy: Rapid Release From Lysolipid Temperature-Sensitive Liposomes

Mills J.K., Needham D., Duke University; presently Sterne, Kessler, Goldstein & Fox, P.L.L.C., US

Despite advances in drug retention and evasion of the body’s defenses, the therapeutic efficacy of many liposomes has been limited by low drug bioavailability within the tumor. Developed in this laboratory in 1996, lysolipid temperature [...]

Nano-Mesosphere Drug Carriers for Localized Cancer Chemotherapy

Goldberg E.P., Almond B.A., Hadba A.R., Cuevas B.J, York A., Enriquez I., University of Florida, US

Aggressive conventional chemotherapy of solid cancers of the breast, lung, prostate, and colorectal area is severely limited by systemic toxic complications. New clinically practical concepts are needed for effective local therapeutic modalities. This paper reports [...]

Electronic Sensing of Antibodies using Carbon Nanotube Devices

Teker K., Sivakumar K., Wickstrom E., Panchapakesan B., University of Delaware, US

Carbon nanotubes (CNTs) are remarkable solid state nanomaterials due to their unique properties such as high surface area, hollow cavities, and excellent mechanical and electrical properties. Interfacing carbon nanotubes with biological materials could enable significant [...]

Optimal Design of Laser Surgery for Cancer Treatment Through Nanoshell-Mediated Hyperthermia Therapy

Feng Y., Rylander N., Bass J., Oden J.T., Diller K., The University of Texas at Austin, US

Recent development of nanoparticle technology and its application in hyperthermia therapies makes it possible to consider optimal control of the temperature field and thermal energy delivered to the tumor region with minimal destruction of surrounding [...]