Biomaterials – Page 64 – TechConnect Briefs

Contrasting agent for magnetic resonance imaging based on nanostructural dispersion of Manganese derivative of phthalocyanine: preliminary investigation results

Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Dolotova O.V., Uchevatkin A.A., Yu. Saveliev O., Yu.Baryshnikov A., Andronova N.V., Oborotova N.A., Kaliya O.L., Pirogov Yu.A., Vorozhtsov G.N., Yu.Baryshnikov A., N.N. Blokhin Russian Cancer Research Center or RAMS, RU

Contrast agents (CA) are used to increase tumor contrasting in magnetic resonance imaging (MRI). The work is devoted to estimation of Manganese chloride tetra-3-phenylthio-tetra-5-tert-buthylphthalocyanine [3-(PhS)4-5-(t-Bu)4PcMnCl] as potential CA for MRI. We have developed the micellar [...]

Enhancement of Photocatalytic Cancer Cell-Killing Activity by Using Ag@TiO2 Core-Shell Composite Nanoclusters

Abdulla-Al-Mamun M., Yang H., Kusumoto Y., Kagoshima University, JP

The photocatalytic cancer cell-killing activities of the Ag@TiO2 core-shell composite colloidal nanoclusters have been investigated on HeLa cells killing under the UV-visible light irradiation. The Ag metal core-TiO2 shell (Ag@TiO2) composite nanocluster photocatalyst with uniform [...]

Intrinsic oxidase activity of cerium oxide nanoparticles facilitate the detection of cancer biomarkers and cancer cells

Perez J.M., Asati A., Santra S., Kaittanis C., Nath S., University of Central Florida, US

Nanomaterials exhibit unique size-dependent physical properties. Thus, identifying novel properties of these materials at the nanoscale, and their applications in energy, catalysis and medicine, among others, is an area of current and intense research. Cerium [...]

Treatment of Breast Cancer with Silver Antitumor Drugs Encapsulated in Biodegradable Polymeric Nanoparticles

Youngs J., Youngs W.J., Robishaw N., Panzner M.J., Hindi K., Medvetz D.A., Youngs J., Youngs W.J., Tessier C., Ditto A., Yun Y.H., Bauer J., Lindner D., University of Akron, US

Our research in cancer focuses on the development of silver carbene complexes (SCCs), for use as antitumor agents. We have found that SCCs have significant activity against a variety of cancers in vitro. Furthermore SCCs [...]

Radiolabeling of Nanoshells with Cu-64 and In-111 for PET and SPECT Imaging in Rats

Xie H., Wang Z., Bao A., Goins B., Phillips W.T., Coleman C.L., Texas Southern University, US

Here we report for the first time the radioactive labeling of gold-silica nanoshells with Cu-64 and In-111. A bifunctional polyethylene glycol (PEG2000) is used as crosslinker to connect nanoshells with DOTA or DTPA, which are [...]

Cancer Nanotechnology

Evaluation of Nanoencapsulated DNA Vaccine for RSV

Boyoglu S., Vig K., Rangari V., Pillai S., Dennis V., Singh S.R., Alabama State University, US

Polymer nanoparticles have been used as carriers to enhance drug delivery. Among them chitosan is the most commonly used carrier, because it promotes long term of incorporated drugs. In the present study,we used DNA vaccine [...]

In Vitro Toxicity Study of Gold and Tin Composite Nanodevices for use in Imaging and Radiotherapy

Khan M.K., Kariapper M.S.T., Kasturirangan V., Nair B., Lesniak W., Balogh L.P., Roswell Park Cancer Institute, US

Composite nanodevices, with PAMAM dendrimer and inorganic metal components, are currently being developed as an exciting nanoplatform for several types of molecularly targeted cancer therapy and imaging. Due to its unique chemical structure of dendrimers, [...]

Inflammation and Cellular Toxicity Study of PAMAM Dendrimer Nanoparticles in Primary Isolated Human Lung Cells

Khan M.K., Kariapper M.S.T., Kasturirangan V., Lesniak W., Sharma M., Baumann H., Balogh L.P., Translational Research Scientist, US

Poly(amidoamine) (PAMAM) based dendrimers are a class of organic particulate nanomaterials with great promise for improvement in cancer imaging and therapy. In this study, we systematically modify terminal groups of the parent generation 5 primary [...]

Use of Nanoparticles as Therapy for Respiratory Syncytial Virus Inhibition

Vig K., Boyoglu S., Rangari V., Sun L., Singh A., Singh S.R., Pillai S., Singh A., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus is the leading cause of severe respiratory illnesses such as bronchiolitis and pneumonia in young children. RSV is a paramyxovirus with negative-sense genomic RNA that encodes for eleven proteins, two of which, [...]