Medical & Biotech – Page 63 – TechConnect Briefs

Biodegradable micro and nanoparticles for controlled drug release

Mattu C., Sartori S., Ranzato E., Boffito M., Li R., Ciardelli G., Politecnico di Torino, IT

Biodegradable polymeric micro and nanoparticles have shown to be promising forms for the delivery of a wide array of drug formulations, such as hydrophobic or hydrophilic active principles, proteins or other bio molecules. The aim [...]

Nanoparticulate systems of Acyclovir for Topical use in Herpes treatment –formulation, characterization and evaluation

Srinivas P., Devaraj R., Sri Venkateshwara College of Pharmacy, IN

Of the numerous drugs that are available for systemic treatment of HSV infection, a cream containing an antiviral agent is still the most convenient method of treating herpes simplex labialis/facialis in the general population. Acyclovir [...]

beta-casein micelles and nanocapsules in drug delivery

Khalfin R.L., Bachar M., Danino D., Technion – Israel Institute of Technology, IL

β-casein, the main protein found in milk, is an amphiphilic molecule that forms micelles both above and below the pI. In the presented work we investigated the possible use of β-casein micelles as a vehicle [...]

Layer-by-Layer Deposition of Cationic Polymers on Gold Nanoparticle for Non-viral Gene Delivery System

Saengkrit N., National Nanotechnology Center (NANOTEC), TH

In this study, gold nanoparticles displayed spherical shapes with an average size of 12 nm were synthesized. The nano-carriers for gene delivery were subsequently developed based on DNA adsorption on the gold/cationic polymer-scaffold. The multilayer [...]

Liposomes loaded with rifampicin and tobromycin for anti-Staphylococcus aureus action

DeSilva M.N., Zhao W.W., Schultz S.T., Whang K., Chu L., Naval Medical Research Unit San Antonio, US

Reducing patient recovery time and potential post surgical complications of warfighters after traumatic injury is of importance for the military. However, a current medical challenge in treating warfighters with traumatic injuries is bacterial infection due [...]

Spectrally-Selective Light-Induced Release from Gold-Coated Liposomes

Leung S.J., Romanowski M., University of Arizona, US

To address unmet medical needs in the area of controlled delivery, we recently presented liposome-supported plasmon resonant gold nanoshells. These composite structures are degradable into components of a size compatible with renal clearance, potentially enabling [...]

Plasmonic Nanobubbles for Intracellular Targeting and Gene Therapy

Lukianova-Hleb E., Wen J., Meteletsa L., Brenner M., Chang J., Lapotko D.O., Rice University, US

Intracellular molecular targeting (IMT) and gene transfection of eukaryotic cells is widely used for research and for developing gene cell therapy. However, the existing IMT methods lack selectivity, efficacy and safety when heterogeneous cell systems [...]

Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-Targeted Gelatin Nanoparticles

Xu J., Amiji M., Northeastern University, US

More than 32,000 patients are diagnosed with pancreatic cancer in the United States per year and the disease is associated with very high mortality. Although gene therapy has tremendous promise, the major challenge has been [...]

Materials for Drug & Gene Delivery

Hybrid bionanomaterials based on nanocrystalline TiO2 and catechol-grafted polymers: the effect of composition and morphology on photo and bioactivity

Cellesi F., University of Manchester, UK

We proposed a synthetic strategy for producing hybrid bionanomaterials based on nanocrystalline TiO2 and catechol-grafted polymers. A sol-gel process in organic solvent was developed to grow TiO2 nanocrystals of highly controlled size and surface chemistry, [...]