Medical & Biotech – Page 177 – TechConnect Briefs

High-Resolution Electrochemical In Situ Printing

Egeland R.D., Southern E.M., Oxamer & Oxford Gene Technology, UK

This work demonstrates a new method for making oligonucleotide microarrays by synthesis in situ. The method uses conventional DNA synthesis chemistry with an electrochemical deblocking step. Acid is delivered to specific regions on a glass [...]

An Chip-based-Instant Protein Micro Array Formation and Detection System

Tseng F-G, Ho C.E., Chen M.H., Chen Y.F., Hung K.Y., Su C-J, Chen M.H., Chen Y.F., Huang H.M., Chieng C-C, National Tsing Hua University, TW

This paper proposes a novel protein micro arrayer employing 3-in-1 chip system, instantly delivering hundreds of biosamples in parallel for disease diagnosis. The 3-in-1chip system included: micro filling chip, micro stamper array and micro bio-reaction [...]

Functional Nanoarrays for Protein Biomarker Profiling

Lynch M., Mosher C., Huff J., Nettikadan S., Xu J., Henderson E., BioForce Nanosciences, Inc., US

The success of microarrays for analyzing nucleic acid and, more recently, protein-protein interactions illustrates the advantages of bioassay miniaturization. However, the current level of miniaturization of useful bioanalytical tools still creates limits in terms of [...]

Detection of DNA Hybridyzation with Impedance Amplifying Labels

Ma K-S, Madou M., Zhou H., Fischetti A., Zoval J., Madou M., University of California Irvine, US

Traditionally used nucleic acid analysis detection platforms rely on fluorescent or radioactive labels. Optical techniques require large and expensive equipment such as automated colorimetric and fluorimetric instruments that greatly increase the cost of the whole [...]

Overview of Overlapping Bio and Nano Technologies

Iyer S., LANL, US

“What is the connection between nanoscience and biology?” “What are biologists doing at Nanotech 2004 and why do you have so many “bio” related sessions?” “So biologists are also jumping on the nanoscience bandwagon.” These [...]

Bio Nano Analysis and Characterization

High Throughput in-silico Screening against Flexible Protein Receptors

Merlitz H., Wenzel W., Forschungszentrum Karlsruhe, DE

Virtual screening of chemical databases to targets of known three-dimensional structure is developing into an increasingly reliable method for finding new lead candidates in drug development. Both better scoring functions and novel docking strategies contribute [...]

Internalization of Nanoparticles in the Middle Ear Epithelium in Response to an External Magnetic Field: Generating a Force

Dormer K., Seeney C., Mamedov A., Mondalek F., University of Oklahoma, Coll. of Med., US

In this study we report the first generation of force by long-term intracellular magnetic nanoparticles (MNP) using a guinea pig middle ear model. Synthesis of magnetite nanoparticles was done using a modified precipitation technique. We [...]

pH Dependent Optical Properties of Surface Modified Gold Nanoparticles Using a Bovine Serum Albumin Coating

Xu Y., Linares K.A., Meehan K., Love B.J., Love N.G., Love B.J., Love N.G., Virginia Polytechnic Institute and State University, US

Use of gold nanoparticles has significant potential in biosensors. Gold’s surface plasmon resonance (SPR) is influenced by the refractive index of the surrounding environment. Changes in the SPR signal can be correlated to changes in [...]

Viruses as Optical Probes

Kwak E-S, Chen C., Cheng Kao C., Cheng Kao C., Schaich W.L., Dragnea B., University of Indiana, US

Viruses consist of a nucleic acide core, the genome, and a protein shell, the viral capsid. Although made out of only a few types of molecular building blocks, virus capsids exhibit a complex set of [...]