Medical & Biotech – Page 171 – TechConnect Briefs

Maxitarg-A Novel Targeting Approach for Hepatic Cancer

Sonavane G.S., Devarajan P.V., Mumbai University Institute of Chemical Technology, IN

The efficacy of current cancer chemotherapy is mainly limited by toxicity associated with the systemic spread of anticancer drugs to normal tissues. Enhancing selectivity or maximizing targeting towards cancer cells would be important approach to [...]

Colloidal Gold Nanoparticles: A Versatile Platform for Developing Tumor Targeted Cancer Therapies

Paciotti G.F., Myer L., Kingston D.G.I., Ganesh T., Tamarkin L., CytImmune Sciences, Inc, US

CytImmune Sciences is developing colloidal gold nanoparticles (cAu) as a platform for tumor targeted drug delivery. Specifically two drugs are discussed: Aurimune-T and AuriTax. Aurimune-T is manufactured by covalently linking molecules of TNF and Thiol-derivatized [...]

The Use of Ligand Conjugated Superparamagnetic Iron Oxide Nanoparticles (SPION) for Early Detection of Metastases

Leuschner C., Kumar C., Urbina M.O., Zhou J., Soboyejo W., Hansel W., Hormes F., Pennington Biomedical Research Center, US

Breast cancer is the most common cause of cancer death in women; more than 75 % of patients die from skeletal metastases. The accurate diagnosis of metastatic disease is therefore crucial for treatment and survival. [...]

Circulating Tumor Cells: Capture with a Micromachined Device

Mohamed H., Murray M., Turner J.N., Caggana M., New York State Department of Health, US

The isolation and analysis of circulating tumor cells (CTCs) from blood is the subject of intense research. Tests to detect metastasis are available but progress is hampered by the lack of tumor-specific markers and predictable [...]

Nanotechnology for Cancer

Glucose Sensors Based on Glucose Oxidase Immobilized in Polypyrrole-Polyacrylamide Microparticles

Rubio-Retama J., Mecerreyes D., University Complutense, ES

Soluble, polypyrrole has been synthesized by the incorporation of the sulphonate dopant anion which renders the polymer soluble in water. The soluble polypyrrole was incorporated in the aqueous phase of a W/O concentrated emulsion, together [...]

Behavior of Living Human Neural Networks on Microelectrode Array Support

Pizzi R., Gelain F., Fantasia A., Rossetti D., Vescovi A., University of Milan, IT

Researchers of the Department of Information Technologies of the University of Milano and of the Stem Cells Research Institute of the DIBIT-S. Raffaele Milano are experimenting the growth of human neural networks of stem cells [...]

Bio-Impedance Sensing Device (BISD) for Detection of Human CD4+ Cells

Mishra N.N., Retterrer S., Zieziulewicz T.J., Isaacson M., Szarowski D., Mousseau D.E., Lawrence D.A., Turner J.N., New York City Department of Health, US

The aim of this work is to develop a small on-chip bio-impedance sensing device (BISD) to rapidly detect and quantify cells with a specific phenotype in a heterogenous population of cells (e.g., human CD4+ cells [...]

Potentiometric Biosensors Based on Silicon and Porous Silicon

Basu I., Subramanian R.V., Mathew A., Chadha A., Bhattacharya E., Indian Institute of Technology Madras, IN

Detection and estimation of Triglycerides and Urea are clinically important. We report fabrication of potentiometric biosensors based on silicon and porous silicon and estimation of triglycerides and urea based on enzymatic reactions. The sensor is [...]

Micro-Patterning of Ionic Reservoirs within a Double Bilayer Lipid Membrane to Fabricate a 2D Array of Ion-Channel Switch Based Electrochemical Biosensors

Sansiñena J.M., Yee C.K., Sapuri A., Swanson B.I., Redondo A., Parikh A.N., Los Alamos National Laboratory, US

We present a simple approach for the design of ionic reservoir arrays within a double phospholipid bilayer to ultimately develop a 2D array of ion-channel switch based electrochemical biosensors. As a first step, a primary [...]