Papers – Page 235 – TechConnect Briefs

Isolation and Detection of Cancer Related DNA Nanoparticulate Biomarkers Directly from CLL Patient Blood “Rapid Sample to Sequence Diagnostics”

Heller M.J., Marciniak J., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA biomarkers continues to become more widely used for cancer diagnostics and management. Cfc-DNA ranges from nucleosomes and high molecular weight DNA nanoparticulates to 100-200bp fragments. We have [...]

Effects of Titanium Dioxide Nanoparticles (TiO2) on Behavioral Parameters of Rats

Rihane Ben Younes N., Amara S., Mrad I., Omri K., El Ghoul J., El Mir L., El Ghoul J., El Mir L., Jeljeli M., Ben Rhouma K., Abdelmelek H., Sakly M., Faculty of Sciences, TN

Titanium dioxide nanoparticles (TiO2-NPs) have a wide range of applications in many fields. The effects of TiO2 NPs on the central nervous system are still unclear. The present study, we investigated the effects of sub-acute [...]

Cationic polystyrene nanosphere induces autophagy through inhibition of Akt/mTOR and activation of AMPK signaling pathways in macrophage and epithelial cells

Chiu H-W, Xia T., Tsai J-C, Chen C-W, Wang Y-J, National Cheng Kung University, Medical College, TW

Nanoparticles have been used to produce a wide range of products. Those include applications in imaging and drug delivery in medicine. However, the possible adverse biological effects in human being remain unclear. Autophagy is an [...]

Pharmacokinetics and Safety Studies of Low Molecular Weight Heparin Nanoconjugates

Yang T., Bouchard B., Cook A., Hu J., Hao J., Bai S., Husson University, US

Low molecular weight heparins (LMWHs) have received widespread acceptance as the first choice for initial prevention and treatment of venous thromboembolism via subcutaneous injection one to two times daily in the clinic. The need for [...]

Iron-sequestering molecules play a pivotal role in the mechanism of toxicity of SWNTs on fungal and bacterial cells

Chaves J.S., Chaves S.J., Zuniga P., Chaves J.S., Chaves S.J., Instituto Tecnologico de Costa Rica, CR

In this study we described that iron-sequestering molecules are responsible for the toxicity of iron containing SWNTs to microorganisms. After incubating different concentrations of functionalized SWNTs with bacteria and fungal cells, it was found that [...]

Magnetic Targeting of Human Aortic Smooth Muscle Cells for Rapid Closure and Healing of Intracranial Aneurysm/Pseudoaneurysm

Arias S.L., Alucozai M., Pastrana F., Reece L.M., Kempaiaih R., Pavon J.J., Allain J.P., Purdue University, US

A novel approach is proposed in this study using a magnetic strategy to address the current disadvantages of detachable coils and stent grafts for aneurysm/pseudoaneurysm treatment. It consists of a patch facing the aneurysm neck [...]

Noble metal nanoparticles for plasmonic photothermal therapy of atherosclerosis

Kharlamov A., Gabinsky J., Erasmus University Medical Center, NL

Background: Our previous bench studies PLASMONICS and NANOM First-in-Man trial documented TAV reduction up to unprecedented 79.4 and 60.3 mm3 respectively with high level of safety and feasibility. Methods: The completed randomized two arm (1:1) [...]

Effects of ZnO nanoparticles and ZnCl2 solution on rat liver and kidney

Ben Rhouma K., Ben Slama I., Amara S., Rihane Ben Younes N., Mrad I., Omri K., El Ghoul J., El Mir L., El Ghoul J., El Mir L., Ben Rhouma K., Ben Slama I., Abdelmelek H., Sakly M., Faculty of Sciences, TN

Recent studies have shown that Zn2+ is released from the surface of ZnO NPs when they are suspended in an aqueous state.The aim of this study was to evaluate the effects of ZnO nanoparticles (ZnO-NPS) [...]

Reversing Coagulopathy and Internal Hemorrhage with Functionalized Nanoparticles

Kudela D., May-Masnou A., Smith S.A., Braun G., Pallaoro A., Chuong T., Morrissey J.H., Stucky G.D., University of Californi, Santa Barbara, US

Uncontrolled hemorrhage is a major cause of preventable death. Wound treatment focuses on using nanostructured oxide and clay-based materials to quicken clot formation. Internal injuries further complicate treatment due to inaccessibility. In response to severe [...]

Application of superparamagnetic nanoparticles for magnetically guided release of anti-cancer drug: An Ivvivo study on Rats

Choubey J., Swami M., Rani Durgawati Vishwavidyalya, Jabalpur, IN

By using appropriate magnetic parameters, 50-80% of the injected nanoparticles could be targeted, thus eliminating systemic distribution and subsequent toxicity of the entrapped agent. In this report we present data on the use of magnetic [...]