Papers – Page 234 – TechConnect Briefs

A safer-by-design formulation concept for flame-generated engineered nanomaterials

Gass S., Pyrgiotakis G., Cohen J.M., Sotiriou G.A., Pratsinis S.E., Demokritou P., Harvard School of Public Health, US

As more consumers and factory workers become exposed to engineered nanomaterials (ENMs), the question of exposure risks is rapidly gaining importance. Engineering less toxic ENMs that maintain valuable functional properties is therefore crucial to the [...]

Cellular uptake and cytotoxic effect of broccoli phytochemical based gold nanoparticles (B-AuNPs): Enhanced cancer therapeutic efficacy

Khoobchandani M., Katti K., Katti K.V., Zambre A., Katti K., Katti K.V., University of Missouri, US

The interaction phytochemicals from Broccoli with gold salt results in dual reduction and surface capping to produce well-defined stable and biocompatible gold nanoparticles. The core sizes of B-AuNPs are in the range of 10–20 nm [...]

pH Responsive Polymeric Nanoparticles Fabricated by Dispersion Polymerization as a Platform for the Delivery of Anticancer Drugs

Puri R., Berhe S., Akala E., Howard University, US

In diseased conditions such as tumors, pH is slightly more acidic than in the blood. The endocytic pathway of cells begin near the physiological pH of 7.4, but it drops to a lower pH of [...]

The Development of Stealth Poly-Ɛ-Caprolactone Nanoparticles For the Delivery of Bioactive Agents

Ogunwuyi O., Akala E., Howard University, US

Polyesters have gained a lot of prominence because of their use in drug delivery. They are the most widely used polymers in biomedical applications because they are biocompatible, non-immunogenic, non-toxic and are approved for use [...]

Synthesis of amphiphilic block copolymers to deliver HSP90 inhibitors for colorectal tumors

Lin C.Y., Shieh M.J., National Taiwan University, TW

In this article, we present pH-sensitive and small size nanoparticles as carrier to encapsulate 17-AAG. We anticipate that this platform will provide a new strategy for cancer therapy.

Lipopolymeric nanoparticles: platform technology for aerosolized combination chemotherapy

Kaur S., Banerjee R., Indian Institute of Technology - Bombay, IN

In the present study, we have conceptualized and formulated a novel delivery vehicle which includes a combination of lipid nanovesicles and polymeric nanoparticles. Main aim of the study is to devise a nanoscale platform technology [...]

Superparamagnetic Iron Oxide Nanoparticles as Drug Delivery Vehicles

Vig K., Casey K., Tiwari P.M., Miller M., Samant R., Singh S.R., Alabama State University, US

In recent years, nanotechnology has emerged as one of the most promising fields for biomedical applications and healthcare. The use of nanoparticles has earned much attention due to their small size, high surface area to [...]

Highly sensitive detection of cancer biomarker EGFR by PicoTREC-SERS

Xiao L., Harihar S., Wu Y., Welch D.R., Zhou A., Utah State University, US

It is reported that for women in the U.S., breast cancer death rates are higher than those for any other cancer, besides lung cancer. Considering the fact that approximately 70–80% of breast carcinomas overexpress the [...]

Metastatic diagnosis of colon cancer by vertically aligned carbon nanotube based electromechanical biosensor

Abdolahad M., Taghinejad H., Taghinejad M., Taghinejad H., Taghinejad M., Janmaleki M., Mohajerzadeh S., University of Tehran, IR

vertically aligned carbon nanotube based electrical biosensor was demonstrated as a more rapid, sensitive and specific device for metastatic diagnosis of colon cancer cells based on the mechanical entrapment of metastatic cancer cells on vertically [...]

Bio-imaging of colorectal cancer models using a CK19-bioconjugated Quantum Dot Nanoprobe

Gazouli M., Nikiteas N., Anagnou NP., Kelekis N., Efstathopoulos E., School of Medicine University of Athens, GR

The aim of the study was to develop and validate a QD-nanoprobe for the detection of CK19 protein for in vivo colorectal cancer molecular targeting. QDs with a maximum emission wavelength of 655 nm, were [...]