Chibli H., Carlini L., Park S., Dimitrijevic N., Nadeau J.L.
McGill University, CA
Keywords: cancer imaging, InP, reactive oxygen species, toxicity
We synthesised Indium phosphide (InP) quantum dots (QDs) with different shell layer. We demonstrate highly fluorescent labeling of cell lines after nonspecific endocytosis of the QD. With spin-trap electron paramagnetic resonance (EPR) spectroscopy and reporter assays we determined the nature of reactive oxygen species generated. The sulforodhamine B (SRB) viability assay indicates very low cytotoxicity in all cell line tested. These data indicate that straightforward methods of synthesis and solubilization result in InP QDs that are a viable alternative to cadmium-containing particles for biological applications.
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 13, 2011
Pages: 133 - 136
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Diagnostics & Bioimaging, Materials Characterization & Imaging
ISBN: 978-1-4398-7138-6