Choi Y., Torikai H., Lee D.A., Lee D.Y., Li K.C., Li Z., Lo D., Qin G., Tung C.H., Tasciotti E., Raphael R., Biswal S.L., Ang S., Lee D.A., Lee D.Y., Li K.C., Li Z., Cooper L.J.N.
M.D. Anderson Cancer Center, US
Keywords: electroporation, gold nanoparticle, indium, T cell
we have developed a high throughput electroporator (HiTE) to manipulate large numbers (~10^9) of T cells ex vivo for clinical uses. HiTE is designed to electro-transfer RNA species to redirect T-cell specificity and gold nanoparticles (Au-NPs) that can be functionalized to enhance T-cell biology. By introducing both transgenes and Au-NPs we are generating T cells that can be rapidly modified to act as a drug-delivery system for targeted therapy of lung cancer.
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Pages: 376 - 379
Industry sector: Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology
ISBN: 978-1-4398-3415-2