tumor – TechConnect Briefs

Application Magnetite of Nanoparticles (ICNB Preparation) as Magnetically-Resonant Contrasting Means During Visualization of Tumours

Belousov A.N., Laboratory of Applied Nanotechnology Belousova A.N., UA

In investigation on animals (Vistar rats) was proof that magnetite of nanoparticles (ICNB) are contrast means for malignant tumour visualization. Was been shown that magnetite of nanoparticles have contrast effect when performing magnetic resonance imaging [...]

Application Magnetite of Nanoparticles (ICNB Preparation) as Magnetically-Resonant Contrasting Means During Visualization of Tumours

Belousov A.N., Laboratory of Applied Nanotechnology Belousova A.N., UA

In investigation on animals (Vistar rats) was proof that magnetite of nanoparticles (ICNB) are contrast means for malignant tumour visualization. Was been shown that magnetite of nanoparticles have contrast effect when performing magnetic resonance imaging [...]

Mechanism of Nitroimidazole Coated Magnetic Nanoparticles Embedded in Micro-organisms as Delivery Systems

Goel N., Sharma R., Post Graduate Institute of Medical Science, IN

Avirulent Bacteria and parasites act as “tiny missile like carriers” capable to carry the magnetic nanoparticles (NMP) together with anticancer or radiosensitizer drugs at the tumor site. We compared the iron-oxide particles binding characteristics with [...]

Temperature Sensitive Liposomes for Local Drug delivery Using Focused Ultrasound

Larabi M., Mackanos M., Shinde R., Contag C., Guccione S., Stanford University, US

Local delivery of therapeutic drugs will increase drug concentration at the site of treatment for maximum efficacy, and reduce systemic drug exposure. The encouraging results obtain in first phase of the clinical study of doxorubicin [...]

Spatio-temporal Tumor Model for Analysis and Mechanism of action of Intracellular Drug Accumulation

Mishra S., Katiyar V.K., Arora V., Haridwar, IN

We have developed a one-dimensional tumor simulator to describe the biodistribution of chemotherapeutic drugs to a tumoral lesion and the tumor cell’s response to therapy. A three-compartment model is used for drug dynamics within the [...]

Pharmacokinetic study of PEGylated plasmon resonant gold nanoparticles in tumor-bearing mice

Kogan B.Ya., Andronova N.V., Khlebtsov B.N., Khlebtsov N.G., Khlebtsov B.N., Khlebtsov N.G., Rudoy V.M., Dement’eva O.V., Sedykh E.M., Bannykh L.N., FGUP “GNC “NIOPIK”, RU

Gold nanorods and gold nanoshells have been synthesized. Nanorods have length of 50 nm, diameter of 15-20 nm. Nanoshells have 80 nm silica core diameter with 25 nm thick gold shells. Then poly(ethylene glycol) molecules [...]

Diffusion of Nanoparticles through the Tissues in Experiment

Reshetov I.V., Frank G.A., Sukharev S.S., Efremov G.D., Danileico Yu.C., Timoshenko V.Yu., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

We have created nanocrystals of silicon with sizes in the greatest measurement in the average 50 nm (from 4 to 100 nm), and nanocrystals of the oxide of aluminum with the adsorbed molecules of phthalocyanines, [...]

Laser Heating of Sulphuretted Carbon Nanoparticles Inhibits Tumor Growth

Kogan B.Ya., Yakubovskaya R.I., Pankratov A.A., Andreeva T.N., Kvacheva L.D., Titov A.A., Puchnova V.A., Feysulova R.A., Vorozhtsov G.N., Organic Intermediates & Dyes Institute, RU

Light-absorbing nanoparticles incorporated in a tissue can be heated by short-pulsed laser irradiation up to several thousand Kelvin degrees. Average tissue temperature may be kept normal if the concentration of these particles is low. Antitumor [...]

Mathematical Modeling of Chemotherapy Strategies in Vascular Tumor Growth using Nanoparticles

Mishra S., Katiyar V.K., Arora V., Indian Institute of Technology, Roorkee, IN

Throughout various fields of science and technology, a push towards the use of nanoscale technology is well underway. One area where nanoscale work is already well underway is within the field of drug delivery.In this [...]

Role of immunoregulators as possibility of tumor hypoxia-induced apoptosis

Sharma R., Kwon S., Chen C-J., Columbia University, US

IL-1, TNF-α and INF-γ cytokines stimulate in nitric oxide production and result with inflammation manifested by apoptosis and hypoxia. We propose that extent of inflammation leading to hypoxia initially and programmed cell death later both [...]