SERRS – TechConnect Briefs

Intracellular Analysis by SERRS and Nanoparticles

Stevenson R., Senior L., Alexander J., Geboers M., Faulds K., Graham D., University of Strathclyde, UK

We report the first use of ‘bare’ nanoparticles as both a cellular delivery vehicle and a spectroscopic detection platform to enable surface enhanced resonance Raman scattering (SERRS) detection. We have shown how this approach can [...]

Dye Coded Nanoparticle as SERRS Labels for Ultrasensitive Detection of Proteins and Antibodies

Stevenson R., Stokes R.J., Ingram A., Faulds K., Graham D., The University of Strathclyde, UK

We have developed a novel surface enhanced resonance Raman scattering (SERRS) detection method that is amenable for almost any biological target. By utilising the information rich spectrum obtained from SERRS we show that we can [...]

Creation of an Aptamer Nanobiosensor for Ultra-Sensitive Detection of Heart Failure

Darnaud M., Ricketts A., Graham D., University of Strathclyde, UK

This project focuses on discovering a new aptamer sequence that binds specifically and with high affinity to Brain Natriuretic Peptide (BNP), which is indicative of the early stages of heart failure. A library of random [...]

Single Base Mismatch Determination using DNA – Silver Nanoparticle Conjugates

Thompson D., Faulds K., Smith W.E., Graham D., University of Strathclyde, UK

Modification of oligonucleotides with gold nanoparticles was first reported ten years ago and opened up several new avenues of research as they can be used as a novel nanostructured building material but the conjugate can [...]