selectivity – TechConnect Briefs

How does nanoparticle design affect targeting selectivity: computer modeling

Dormidontova E.E., University of Connecticut, US

One of the areas of active development of modern nanomedicine is application of polymer tethered nanoparticles for drug/gene delivery and imaging. The optimal nanoparticle design for targeting one type of cell may be quite different [...]

Nanostructured Biomimetic Pyruvate Dehydrogenase Complex (PDC) Sensors Selectively Detect Single Brain Cancer Cell and Have the Ability to Mimic the “ATP LID”

Chen E.T., Thornton J., Ngatchou C., Duh S-H, Kissinger P.T., Advanced Biomimetic Sensors, Inc., US

Diseases such as cancer, diabetes mellitus, and brain injury can be caused by lack of conformational change in the pyruvate dehydrogenase complex (PDC). The known “ATP Lid” for the function of PDC is comprised by [...]

Functionalized Carbon Nanotube–Based Sensors for Detecting a Trace Quantity of 2,4-Dinitrotoluene Explosive Vapors, with Selectivity

Kayastha V., Jones C., Landorf C., Brewer Science, Inc, US

We have developed a new sensing material that can selectively detect explosive molecules such as 2,4-dinitrotoluene and 2,4,6-trinitrotoluene; and have successfully demonstrated functional chemical sensors using this new material. The newly developed sensing material is [...]

Selectivity study for a reagent-less and enzyme-free nanopore glucose sensor against interferences of non-glucose sugars and other substances

Chen E.T., Duh S-H, Ngatchou C., Thornton J.T., Kissinger P.T., Advanced Biomimetic Sensors, Inc., US

Accurate blood glucose monitoring is critical for diabetes patients to tightly control their diseases. For decades, blood glucose monitoring technology has relied on the use of reagents, including enzymes, mediators, and buffers. This monitoring technology [...]

Carbon nanotubes transistors based Selective Gas sensors : from laboratory to mass production

Gorintin L., Thales Research and Technology, FR

Gas sensing Property of Carbon NanoTube (CNT) transistors are known for several years to be extremely sensitive to gases and thus have been proposed as gas sensors for several applications. But their versatility and their [...]

Novel Nanostructures for Solid State Alcohol Breath Analyzers

Tricoli A., Righettoni M., Pratsinis S.E., Swiss Federal Institute of Technology, CH

Solid state alcohol breath analyzers are commonly used by the law enforcement authorities, due to high sensitivity toward ethanol, their portability and fair response and recovery times. Common materials for the synthesis of the sensitive [...]

Influence of liposome size on accumulation in tumor and therapeutic efficiency of liposomal near-IR photosensitizer for PDT based on aluminum hydroxide tetra-3-phenylthiophthalocyanine

Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Pevgov V.G., Lukyanets E.A., Oborotova N.A., Gurevich D.G., Zorin A.A., Derkacheva V.M., Smirnova Z.S., Loschenov V.B., Vorozhtsov G.N., Baryshnikov A.Yu., A.M. Prokhorov General Physics Institute of RAS, RU

Size of nanoparticles is considered to be the one of main factors determining the efficiency of nanostructural antitumor drugs. Current work was performed to estimate the influence of liposomal size distribution on level and selectivity [...]

New efficient nanostructural near-IR photosensitizer for photodynamic therapy of malignancies based on micellar dispersion of zinc octa-4,5-decylthio-3,6-chloro-phthalocyanine

Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Lukyanets E.A., Negrimovsky V.M., Barkanova S.V., Zorin A.A., Umnova L.V., Oborotova N.A., Loschenov V.B., Vorozhtsov G.N., Baryshnikov A.Yu., N.N.Blokhin Russian Cancer Research Center of RAMS, RU

The work is devoted to investigation of new nanostructural photosensitizer on a base of zinc octa-4,5-decylthio-3,6-chloro-phthalocyanine solubilized in micellar dispersion. Photosensitizer possesses its absorption maximum at about 730 nm and can be considered promising for [...]

Gold Removal and Recovery using Mesoporous Silica Adsorbents

Lam K.F., Yeung K.L., McKay G., Hong Kong University of Science and Technology, CN

This work investigates the selective removal of dissolved metal ions from aqueous solutions using MCM-41 adsorbents grafted with different chemical moieties. A systematic study was conducted to understand the adsorption mechanisms, in order to better [...]

Simulation Studies of Channels in Biological Membranes

Henderson D., Busath D.D., Rowley R.L., Crozier P.S., Boda D., Brigham Young University, US

The results of our recent studies of the selectivity of a calcium channel by means of a Monte Carlo simulation and of the conductance of ions in a model channel by means of a molecular [...]